Results 51 to 60 of about 10,778,845 (284)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

open access: yesFEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan   +2 more
wiley   +1 more source

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

open access: yesFEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield   +3 more
wiley   +1 more source

Alternative Theories of CP violation [PDF]

open access: yes, 1997
Recent improvements to the limit of Delta M_{B_s} imply that pure superweak theories, while not excluded, no longer provide a good fit to the data. A class of general superweak theories is introduced in which all flavor changing interactions are governed
Achille Stocchi   +4 more
core   +3 more sources

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

open access: yesFEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan   +2 more
wiley   +1 more source

Alternate current machinery — Induction alternators [PDF]

open access: yesProceedings of the American Institute of Electrical Engineers, 1905
In the following pages it is proposed to discuss some of the elementary phenomena found while studying the performance of alternators excited by alternating currents. In a second paper the writer intends to deal with the practical application of the principles here described.
Stanley, W.-M., Faccioli, G.
openaire   +3 more sources

An alternative regional strategy [PDF]

open access: yes, 2004
Regions, this extract suggests, cannot bring about regional inequality without significant national level action. The key, it is claimed, is a ‘national commitment to decentre the economy’.
Amin, Ash, Massey, Doreen, Thrift, Nigel
core  

Alternative to Domain Wall Fermions [PDF]

open access: yes, 2001
An alternative to commonly used domain wall fermions is presented. Some rigorous bounds on the condition number of the associated linear problem are derived.
Avron   +16 more
core   +1 more source

The multidrug and toxin extrusion (MATE) transporter DTX51 antagonizes non‐cell‐autonomous HLS1–AMP1 signaling in a region‐specific manner

open access: yesFEBS Letters, EarlyView.
The Arabidopsis mutants hls1 hlh1 and amp1 lamp1 exhibit pleiotropic developmental phenotypes. Although the functions of the causative genes remain unclear, they act in the same genetic pathway and are thought to generate non‐cell‐autonomous signals.
Takashi Nobusawa, Makoto Kusaba
wiley   +1 more source

Variations on an American dream: alternative homeownership models [PDF]

open access: yes
With homeownership central to the national economy and U.S. housing policy, the drop in homeownership rates could have long-term negative consequences.
Erin Graves
core  

Home - About - Disclaimer - Privacy