Advanced Science, EarlyView.Whole‐genome analysis of 1,054 chickens reveals three ancestral sources (NWC, SYA, and SHF) with distinct temporal entry patterns into the Tibetan Plateau. Route‐specific selection scans, calibrated against a demographic null, suggest complementary functional enrichments—vascular homeostasis (NWC), calcium signaling and cardiac adaptation (SYA), and ...
Zongyi Zhao +7 more
wiley +1 more source
An Information-Theoretic Model of Abduction for Detecting Hallucinations in Explanations. [PDF]
Entropy (Basel)Galitsky B.
europepmc +1 more source
Personalized Network‐Guided Neuromodulation Enhances Human Working Memory
Advanced Science, EarlyView.A personalized neuromodulation framework combining individualized functional brain network targeting with real‐time neural decoding is introduced. Using concurrent TMS–fMRI, participant‐specific stimulation targets and optimal frequencies are identified. Only optimal‐frequency stimulation improves working memory across sessions.
Ahsan Khan +13 more
wiley +1 more source
Disgust in anorexia nervosa: Testing a theoretical model connecting negative body image to disgust propensity, disgust sensitivity, and self-disgust. [PDF]
PLoS OneBoonstra F +3 more
europepmc +1 more source
On a nonparametric test for linear relationships
In a recent paper Azzalini and Bowman (1993, J. Roy. Statist. Soc. Ser. B 55, 549-559) proposed a pseudolikelihood ratio test for checking the linearity in a homoscedastic nonparametric regression model under a fixed design assumption.
Dette, Holger
core
Advanced Science, EarlyView.This study explores the opposing effects of the mGluR2 and mGluR3 receptors on amyloid precursor protein processing. mGluR2 promotes amyloidogenic cleavage, while mGluR3 favors non‐amyloidogenic pathways. Using a brain‐penetrant nanobody as a mGluR2 positive allosteric modulator, the study uncovers how its chronic activation aggravates amyloid‐β burden
Pierre‐André Lafon +21 more
wiley +1 more source
No stone unturned: Prevalence effects in interactive search are different than those in visual search. [PDF]
Psychon Bull RevDewis H +4 more
europepmc +1 more source
Multimodal Imaging Reveals Rapid Catecholamine Uptake and Release by Neutrophils
Advanced Science, EarlyView.We show that immune cells (neutrophils) synthesize, uptake, and store catecholamine neurotransmitters such as dopamine or adrenaline. They also release them in response to specific stimuli (serotonin), which we directly visualize using fluorescent nanosensors. We further demonstrate that catecholamines affect neutrophil functions (NETosis) and platelet
Jennifer Mohr +19 more
wiley +1 more source
Unintentional benzodiazepine use and frequency of drug checking service utilization: a cross-sectional study. [PDF]
Harm Reduct JAirth L +7 more
europepmc +1 more source
Sustainable Materials Design With Multi‐Modal Artificial Intelligence
Advanced Science, EarlyView.Critical mineral scarcity, high embodied carbon, and persistent pollution from materials processing intensify the need for sustainable materials design. This review frames the problem as multi‐objective optimization under heterogeneous, high‐dimensional evidence and highlights multi‐modal AI as an enabling pathway.
Tianyi Xu +8 more
wiley +1 more source