Results 321 to 330 of about 433,637 (362)
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Abnormalities in the alternative pathway of complement in psoriasis
Clinical and Experimental Dermatology, 1982Summary Some of the immunologic aspects of psoriasis suggest that complement may be involved in the pathophysiology of that disease. The purpose of this work was to examine the complement system in more detail in 20 patients with psoriasis. Classical pathway determinations, RCH50 and factor B levels were normal or elevated.
Joan R.Urmson +7 more
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The alternative pathway of complement and the thrombotic microangiopathies
Transfusion and Apheresis Science, 2016Thrombotic microangiopathies (TMA) are disorders defined by microangiopathic hemolytic anemia, non-immune thrombocytopenia and have multi-organ involvement including the kidneys, brain, gastrointestinal, respiratory tract and skin. Emerging evidence points to the central role of complement dysregulation in leading to microvascular endothelial injury ...
Chia Wei Teoh +2 more
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The Alternative Pathway of Complement Activation
1976Publisher Summary This chapter presents the alternative pathway of complement activation. Two pathways for the recruitment of complement and its biological activities exist in plasma and serum. The first is termed as the “classical pathway,” which is triggered by contact of C1 with immune complexes containing antibodies of the immunoglobulin G (IgG ...
Otto Götze, Hans J. Müller-Eberhard
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Alternative pathway of complement in multiple myeloma
American Journal of Hematology, 1981AbstractThe alternative pathway of complement was studied in 16 newly diagnosed and 2 previously treated patients with multiple myeloma. Functional activity of this pathway was abnormal in 10 of these 18 patients (55%). These abnormalities correlated with depressed levels of alternative pathway components in 3 of 10 patients, but in the remaining 7, no
Eric H. Kraut, Arthur L. Sagone
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The role of antibody in the activation of the alternative complement pathway
Springer Seminars in Immunopathology, 1983The alternative complement pathway can be activated in the absence of specific antibody by the surface of certain cells and particles that provide a microenvironment in which the affinity of the regulatory protein H for surface-bound Cab is low. There is now abundant evidence that antibody can enhance activation.
Douglas T. Fearon +2 more
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Regulation of the alternative pathway of complement by pH.
The Journal of Immunology, 1987Abstract Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired hemolytic anemia. The abnormal PNH erythrocytes are highly susceptible to complement-mediated lysis in vitro, especially at pH 6.4. Lysis has been shown to be due to alternative pathway activation. The purpose of this study was to determine why lysis of PNH erythrocytes is
Z, Fishelson +2 more
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A TODDLER WITH ALTERNATIVE PATHWAY COMPLEMENT DEFICIENCY
Annals of Allergy, Asthma & Immunology, 2018Introduction Complement system is an important component of innate immunity and can be activated through the classical, alternative, and lectin pathways. Patients with complement deficiency (CD) usually present with autoimmune disorders or recurrent infections.
P. Sriaroon, P. Purswani
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Activation of the Alternative Complement Pathway by Torulopsis Glabrata
Scandinavian Journal of Infectious Diseases, 1979Torulopsis glabrata is a yeast-like fungus with increasing importance as an opportunistic human pathogen. The role of serum complement in resistance to this infection was studied by chemotactic and opsonic assays. The results indicate that T. glabrata activates complement via the alternative pathway.
Antonio Ferrante, Y.H. Thong
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Regulation of the alternative pathway of human complement by C1q
Molecular Immunology, 1987The interaction of C1q with C3b and its effect on C3b activities in the alternative pathway of complement (APC) have been studied. Purified C1q markedly inhibited C3b deposition on and lysis of rabbit erythrocytes by the isolated cytolytic APC. It also blocked formation of the C3 convertase, C3b, Bb as well as binding of Factors B and H to sheep ...
Zvi Fishelson, Hans J. Müller-Eberhard
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The spectrum of complement alternative pathway‐mediated diseases
Immunological Reviews, 2008Summary: The complement system has once again come into prominence in the therapeutic development arena. The recent approval of an inhibitory monoclonal antibody, eculizumab, which is directed against complement component C5 for the disease paroxysmal nocturnal hemoglobinuria has provided the initial validation of this system as a therapeutic target ...
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