Results 91 to 100 of about 2,108,518 (265)

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Resistência de genótipos de feijão-caupi ao ataque de Callosobruchus maculatus (Fabr., 1775) (Coleoptera: Chrysomelidae: Bruchinae)

Arquivos do Instituto Biológico
O objetivo deste trabalho foi avaliar a resistência de quatro genótipos de feijão-caupi (Vigna unguiculata) ao caruncho Callosobruchus maculatus (Fabr., 1775). Os genótipos utilizados foram BR 17-Gurguéia, BRS Rouxinol, TE96-290-12G e BRS Guariba.
A.F de Melo, L.S Fontes, D.R.S Barbosa, A.A.R Araújo, E.P.S Sousa, L.L.L Soares, P.R.R Silva   +6 more
doaj  

Laboratory Evaluation of Contact and Feeding Deterrent Effects of Selected Essential Oils Against Different Life Stages of Cylas formicarius (Coleoptera: Brentidae)

Insects
The sweet potato weevil, Cylas formicarius (Fabricius) (Coleoptera: Brentidae), is one of the most destructive pests of sweet potato [Ipomoea batatas (L.) Lam.] crops worldwide. Current management of the sweet potato weevil relies heavily on conventional
Maria Jéssica dos Santos Cabral, Muhammad Haseeb, Otgonpurev Sukhbaatar, Marcus Alvarenga Soares   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Morinda citrifolia Essential Oil: A Plant Resistance Biostimulant and a Sustainable Alternative for Controlling Phytopathogens and Insect Pests

Biology
With the growing demand for sustainable and safe agricultural practices, plant compounds emerge as a solution for biological activities. Here, we evaluated the potential of using Morinda citrifolia essential oil to induce plant resistance and to control ...
Bruna Leticia Dias, Renato Almeida Sarmento, Madelaine Venzon, Luis Oswaldo Viteri Jumbo, Lucas Samuel Soares dos Santos, Wellington de Souza Moura, Dalmarcia de Souza Carlos Mourão, Paulo Ricardo de Sena Fernandes, Taila Renata Neitzke, João Victor de Almeida Oliveira, Tiago Dias, Mateus Sunti Dalcin, Eugênio E. Oliveira, Gil Rodrigues dos Santos   +13 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Potential of Essential Oils from Cymbopogon winterianus Jowitt: Promising Evaluation for the Control of Mollusks and Embryos of Biomphalaria glabrata and Schistosoma mansoni Cercariae

Pharmaceuticals
Background/objectives: Schistosomiasis is a parasitic disease that represents a serious public health problem. An alternative for the control of snails, intermediate hosts of schistosomiasis, is the use of molluskicides.
Keyla Nunes Farias Gomes, Francisco Paiva Machado, Ester Maria Mota, Ana Cláudia Rodrigues da Silva, Mikaella Gonçalves Xavier, Joana Tostes da Cunha e Menezes, Anita Ferreira do Valle, Leandro Louback da Silva, Beatriz de Frias Leite, Leandro Rocha, Robson Xavier Faria   +10 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Development and Population Growth Rates of Sitophilus zeamais (Coleoptera: Curculionidae) Exposed to a Sublethal Concentration of Essential Oil of Piper hispidinervum

Insects
Essential oils have emerged as promising alternatives for pest insect control. However, sublethal effects on insect reproduction and development are rarely explored, despite their relevance to integrated pest management (IPM).
Lucas Martins Lopes, Lêda Rita D’Antonino Faroni, Gutierres Nelson Silva, Douglas Rafael e Silva Barbosa, Marcela Silva Carvalho, Herus Pablo Firmino Martins, Thaís Rodrigues dos Santos, Igor da Silva Dias, Adalberto Hipólito de Sousa   +8 more
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source