Results 171 to 180 of about 24,387,293 (346)

Ectoparasites of medical and veterinary importance: drug resistance and the need for alternative control methods

The Journal of pharmacy and pharmacology, 2015
C. McNair
semanticscholar   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

A Cost-Effectiveness Study of Animal Disease Eradication Strategies: Foot-and-Mouth Disease in Ireland [PDF]

The primary focus of this poster paper is to evaluate the cost-effectiveness of alternative control strategies for a number of simulated outbreaks of Foot-and-Mouth disease (FMD) in four agriculturally diverse Irish regions, examining for the first time,
Dillon, Emma J.
core   +1 more source

An approach to alternative strategies to control avian coccidiosis and necrotic enteritis

Journal of Applied Poultry Research, 2020
P. Adhikari, A. Kiess, R. Adhikari, R. Jha   +3 more
semanticscholar   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Vaporização de ácido acético para o controle pós-colheita de botrytis cinerea em uva 'Itália' Fumigation of 'itália'grape with acetic acid for postharvest control of botrytis cinerea

Revista Brasileira de Fruticultura, 2010
Visando a avaliar o efeito do vapor de ácido acético (AA) como medida alternativa no controle pós-colheita do mofo-cinzento (Botrytis cinerea) em uva 'Itália', foram conduzidos dois ensaios in vivo onde se avaliou o efeito direto e indireto do AA através
Elisangela Clarete Camili, Eliane Aparecida Benato, Sérgio Florentino Pascholati, Patrícia Cia   +3 more
doaj  

New and alternative strategies for the prevention, control, and treatment of antibiotic-resistant Campylobacter.

Translational research : the journal of laboratory and clinical medicine, 2020
Lei Dai, O. Sahin, M. Grover, Qijing Zhang   +3 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Sensitivity of Entomopathogenic Fungi and Bacteria to Plants Secondary Metabolites, for an Alternative Control of Rhipicephalus (Boophilus) microplus in Cattle. [PDF]

Front Pharmacol, 2018
Nardoni S, Ebani VV, D'Ascenzi C, Pistelli L, Mancianti F.   +4 more
europepmc   +1 more source