We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala +15 more
wiley +1 more source
Settling Environmental Disputes using Alternative Dispute Resolution strategies and the impact on tourism activity in South Africa. [PDF]
The field of environmental law is an area of competing interests in which disputes are bound to occur. Environmental issues cannot be perceived as separate from other resources.
Ms. M. van der Bank +1 more
doaj
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
El dominio de la victimología en los métodos alternativos de justicia / Le rôle de la victimologie dans les méthodes alternatives à la justice ordinaire / The role of victimology and the alternative dispute resolution [PDF]
The current circumstances in the criminal justice system is creating a feeling of distrust by the population due to high levels of victimization that comes to suffer the victim throughout the criminal process.
Arrona Palacios Arturo
doaj
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris +10 more
wiley +1 more source
Alternative Dispute Resolution: A Panacea for Retrieval of Expeditious Justice in Pakistan
Samza Fatima, Syed Kaleem Imam
openalex +1 more source
The Appropriate Resolution of Corporate Disputes: A Report on the Growing Use of ADR by U.S. Corporations [PDF]
A quick scan of the business and legal press reveals that, compared with a few years ago, many more disputes are being resolved through negotiation, mediation, and arbitration.
Lipsky, David B., Seeber, Ronald L.
core +1 more source
Alternative Dispute Resolution as Soft Approach for Business Dispute in Indonesia
Alternative Dispute Resolution (ADR) is one solution that can be used as a solution by people in resolving their civil disputes. The dispute that often arises today is related to capital or loans.
A. Ningsih
semanticscholar +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Ukrainian institutions that would facilitate alternative dispute resolution have been in the process of establishment since Ukraine's independence in 1991.
Roksolana KHANYK-POSPOLITAK +1 more
doaj

