Results 41 to 50 of about 1,627,797 (307)

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Sustainable Development is the only path to achieve the green economy

Renewable Energy and Sustainable Development, 2015
Sustainable development is the management of renewable resources for the good of the entire human and natural community. Built into this concept is an awareness of the animal and plant life of the surrounding environment .The goal of sustainable ...
Ahmed Abou Elseoud
doaj   +1 more source

Utilization of Waste for Energy Generation in Clinker Production: Environmental Perspective

Pakistan Journal of Analytical & Environmental Chemistry, 2020
Meeting the increasing energy need from fossil fuels such as coal, oil and natural gas caused the rapid depletion of natural resources. In a world where the need for energy is constantly increasing and resources are getting scarce; it is necessary to ...
Fatma Didem Tunçez
doaj   +1 more source

Typology of the countries of Central and Eastern Europe including the CIS: features of the use of alternative energy [PDF]

E3S Web of Conferences, 2020
The article describes the features of the current state and future development of renewable energy without taking into account the use of water resources in the countries of Central and Eastern Europe (CEE) and European Commonwealth of Independent States
Jednak Sandra, Shuvalova Olga, Rodionova Irina   +2 more
doaj   +1 more source

Energy security issues in contemporary Europe [PDF]

, 2018
Throughout the history of mankind, energy security has been always seen as a means of protection from disruptions of essential energy systems. The idea of protection from disorders emerged from the process of securing political and military control over ...
Abrhám, Josef, Britchenko, Igor, Garškaitė-Milvydienė, Kristina, Jankovic, Marija   +3 more
core  

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Comparative analysis of traditional and alternative energy sources [PDF]

Acta Montanistica Slovaca, 2008
The presented thesis with designation of Comparing analysis of traditional and alternative energy resources includes, on basisof theoretical information source, research in firm, internal data, trends in company development and market, descriptionof the ...
Adriana Csikósová, Lívia Bodonská
doaj  

Alternative Energy Usage Types in Buildings and a Proposal for a Generator Working with Wave Energy

Journal of Architectural Sciences and Applications, 2021
The decrease in non-renewable resources, and global warming problem in the world is increasing the interest and demand for alternative energy sources. In addition to the investments made in renewable energies such as solar and wind in various countries ...
Cüneyt Diri, Sinan Gülçelik
doaj   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Progress on rock thermal energy storage (RTES): A state of the art review

Energy Science & Engineering
Thermal energy is one of the most widely encountered energy forms in our daily life. To ensure efficient utilization and conversion of this energy, the balance between supply and demand needs to be maintained.
Leyla Amiri, Hamidreza Ermagan, Jundika C. Kurnia, Ferri Hassani, Agus P. Sasmito   +4 more
doaj   +1 more source