Results 51 to 60 of about 1,048,046 (289)

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source

Challenges and Prospects of Evaluation of Programs in Public Finance Management in Georgia [PDF]

Вісник Київського національного університету імені Тараса Шевченка. Серія Економіка, 1899
The establishment of a program assessment mechanism in the public sector of Georgia is an important element for supporting the ongoing public finance management reform and improving the budgeting process as well as enhancing the budget planning stage and
D. Oboladze, R. Otinashvili
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Alternative Dispute Resolution for Islamic Finance in Malaysia

MATEC Web of Conferences, 2018
The law lays down rules that govern private disputes, self-help actions or open-conflicts that may occur in the society. Here, courts, tribunals, arbitration and other dispute resolution forums are the main secular institutions in dispensing just ...
Dahlan N. Khalidah
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Finance alternatives – electronic financial innovation and economic growth

Acta Universitatis Lodziensis. Folia Oeconomica, 2016
The financial crisis of 2008 disclosed the weaknesses of the traditional banking system and prompted market participants, especially from the private sector to seek alternative methods of financing.
Aneta Ewa Waszkiewicz
doaj   +1 more source

CROWDFUNDING - A VIABLE ALTERNATIVE TO FINANCE SMALL AND MEDIUM ENTERPRISES [PDF]

Challenges of the Knowledge Society, 2022
The resumption of economic activity after the lockdown imposed by the need to stop the Covid-19 pandemic is a major imperative for any of the states in the world that have faced this scourge. Among the most affected corporate organizations were small and
Emilia Cornelia STOICA, Elena Mihaela ILIESCU   +1 more
doaj  

Alternative modes of financing [PDF]

, 2021
Οι χρηματοπιστωτικές αγορές είθισται να καθοδηγούνται από τη διαθέσιμη πληροφορία που κατέχουν οι επενδυτές. Εάν οι αγορές ήταν απολύτως αποτελεσματικές, οι επενδυτές δεν θα είχαν κίνητρο να ξοδεύουν χρήματα ή χρόνο για να συλλέξουν πληροφορίες για τα χρηματοοικονομικά προϊόντα, διότι σε αυτή την περίπτωση οι πληροφορίες θα αποτυπώνονταν άμεσα στις ...
openaire   +1 more source

Asset pricing models, the labour theory of value and their implications for accounting [PDF]

, 2004
The paper analyses the social components of two theories of central importance to accounting and finance. It shows that modern finance theory is unable to account for value and that although its canon and major assumptions successfully obfuscate real ...
Toms, S.
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