Results 71 to 80 of about 2,148,223 (284)

Emerging role of ARHGAP29 in melanoma cell phenotype switching

Molecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster, Melanie Kappelmann‐Fenzl, Anja Katrin Bosserhoff, Nicole Rachinger   +3 more
wiley   +1 more source

Experimentally Measured Thermal Masses of Adsorption Heat Exchangers

Energies, 2020
The thermal masses of components influence the performance of many adsorption heat pump systems. However, typically when experimental adsorption systems are reported, data on thermal mass are missing or incomplete.
Kyle R. Gluesenkamp, Andrea Frazzica, Andreas Velte, Steven Metcalf, Zhiyao Yang, Mina Rouhani, Corey Blackman, Ming Qu, Eric Laurenz, Angeles Rivero-Pacho, Sam Hinmers, Robert Critoph, Majid Bahrami, Gerrit Füldner, Ingemar Hallin   +14 more
doaj   +1 more source

Econometric analyses with backdated data: unified Germany and the euro area [PDF]

In this paper we compare alternative approaches for the construction of time series of macroeconomic variables for Unified Germany prior to 1991, and then use them for the construction of corresponding time series for the euro area.
Angelini, Elena, Marcellino, Massimiliano   +1 more
core  

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

How Important Is the Family? Evidence from Sibling Correlations in Permanent Earnings in the US, Germany and Denmark [PDF]

, 2011
This paper is the first to analyze intergenerational economic mobility based on sibling correlations in permanent earnings in Germany and to provide a cross-country comparison of Germany, Denmark, and the US.
Schnitzlein, Daniel D.
core   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Alternative for Germany — more than a fleeting phenomenon

Society and Economy, 2017
In this paper, the prospects of the political party Alternative for Germany (AfD) are examined on the basis of demand and supply factors which favor a party’s electoral breakthrough and longtime persistence. It will be argued that although the party is currently profiting mainly from growing disillusion with Chancellor Angela Merkel’s open-door refugee
openaire   +1 more source

From the Eurozone Debt Crisis to the Alternative for Germany [PDF]

Frontiers in Political Science, 2020
The sudden rise and subsequent radicalization of the “Alternative for Germany” (AfD) has been one of the politically most important consequences of the Eurozone debt crisis in Germany, both in relation to domestic politics and in the broader context of European-level right-wing populism.
openaire   +1 more source

Parasites and Raven Mothers: A German-Japanese Comparison on (Lone) Motherhood [PDF]

Having a child out of wedlock used to be associated with shame and scorn. This is mostly not the case anymore in the western world. Therefore, freed from social sanctions, single motherhood has become an additional family-choice alternative for women ...
Anna Klabunde, Evelyn Korn
core