Results 91 to 100 of about 2,647,291 (284)
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
The choice between two hypothesis tests [PDF]
Most standard hypothesis tests have high power only against a limited space of alternative hypotheses. With the advent of new tests for the same hypothesis, claimed to have higher power for some alternatives, but lower for other, the practitioner has to ...
Ruist, Erik
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Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Testing learning as alternative to the blank slate hypothesis in the honey bee, Apis mellifera
PLoS ONEReliable recognition of nestmates and discrimination against non-nestmates is key to the integrity of social insect colonies. Cuticular hydrocarbon profiles play a key role in this recognition process in many species, including honey bees.
Olav Rueppell +3 more
doaj +2 more sources
The lack of reproducibility in research: How statistics can endorse results
Mètode Science Studies Journal: Annual Review, 2015 Scientific research is validated by reproduction of the results, but efforts to reproduce spurious claims drain resources. We focus on one cause of such failure: false positive statistical test results caused by random variability.
Scott Goddard, Valen Johnson
doaj +1 more source
Twenty Years of Working Towards a Sustainable Southeast Asia: 1993 -- 2013 [PDF]
, 2013 The Southeast Asia program first set about testing hypotheses applicable to each of the three ecosystem zones. On the forest margins, the hypothesis was that complex agroforests provided a superior alternative for small-scale farmers to either food-crop ...
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Econometric Research in Finance, 2019 In empirical studies of the efficient market hypothesis using a classic approach, attention has generally been paid to the weak form of performance; other aspects of efficiency, such as informational efficiency, have not been addressed.
Mostafa Raeisi Sarkandiz +1 more
doaj +1 more source
Goodness-of-fit tests in mixed models. [PDF]
Mixed models, with both random and fixed effects, are most often estimated on the assumption that the random effects are normally distributed. In this paper we propose several formal tests of the hypothesis that the random effects and/or errors are ...
Claeskens, Gerda, Hart, Jeffrey D.
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Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source