Results 61 to 70 of about 2,647,291 (284)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

The “Gateway” hypothesis: evaluation of evidence and alternative explanations

Harm Reduction Journal
Background Electronic nicotine delivery systems (ENDS) offer a substantial harm reduction opportunity for adults who smoke and are unlikely to quit. However, a major concern about ENDS is their use by non-smoking youth, and particularly whether ENDS are ...
Arielle Selya
doaj   +1 more source

The Effects of Teaching Technique and Reading Habit towards Student’s Writing Skill at Junior High School in Serang

Journal of English Language Studies, 2017
The purpose of this research is to know the interactive effects of teaching technique, peer evaluation and reading habit towards student’s writing skill at Junior High School in Serang.
Arifiatul Hasanah
doaj   +1 more source

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions

FEBS Letters, EarlyView.
Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf, Nicholas F. Downing, Kaitlyn M. Mills, Samuel C. Metcalfe, Alexander E. Kritzer, Lindsey D. Mayo, Peter C. Hollenhorst   +6 more
wiley   +1 more source

Raman Scattering by Atomic Hydrogen in Photodissociation Regions: An Alternative to the Polycyclic Aromatic Hydrocarbons Hypothesis

The Astrophysical Journal, 2023
Photodissociation regions (PDRs) illuminated by high temperature ( T > 10 ^4 K) radiation fields display characteristic optical to midinfrared spectral features: emission bands that cluster around the blue limits of hydrogen series, an extended red ...
Frédéric Zagury
doaj   +1 more source

A Refined Similarity Hypothesis for Transverse Structure Functions

, 1997
We argue on the basis of empirical data that Kolmogorov's refined similarity hypothesis (RSH) needs to be modified for transverse velocity increments, and propose an alternative.
Cao, Nianzheng, Chen, Shiyi, Nelkin, Mark, Sreenivasan, Katepalli R.   +3 more
core   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

FEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva, Ariann E. Mendoza‐Martínez, P. Abril Medina‐Flores, Carlos Campero‐Basaldua, Alexander DeLuna, Soledad Funes   +5 more
wiley   +1 more source

An Alternative to Null-Hypothesis Significance Tests [PDF]

Psychological Science, 2005
The statistic Prep estimates the probability of replicating an effect. It captures traditional publication criteria for signal-to-noise ratio, while avoiding parametric inference and the resulting Bayesian dilemma. In concert with effect size and replication intervals, Prep provides all of the information now used in evaluating research, while ...
openaire   +2 more sources