Results 81 to 90 of about 2,647,291 (284)
Multiple Testing With an Empirical Alternative Hypothesis [PDF]
, 2006 An optimal multiple testing procedure is identified for linear hypotheses under the general linear model, maximizing the expected number of false null hypotheses rejected at any significance level.
Signorovitch, James E
core +1 more source
The local power of the gradient test
, 2010 The asymptotic expansion of the distribution of the gradient test statistic is derived for a composite hypothesis under a sequence of Pitman alternative hypotheses converging to the null hypothesis at rate $n^{-1/2}$, $n$ being the sample size ...
A. Wald +19 more
core +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
New Polystochastic Statistical Inference in Social Sciences - Defining new Rules and Thresholds
Revija za Elementarno IzobraževanjeThe Null Hypothesis Significance Testing (NHST) framework has sparked considerable debate within the scientific community, leading to numerous studies advocating for a re-evaluation of the current system.
Sinisa Opić
doaj +1 more source
PIH and ROT alternative in view of the intertemporal non-separability of preferences: empirical findings from a Japanese panel data [PDF]
This paper describes an empirical investigation into the permanent income hypothesis (PIH) and the rule-of-thumb (ROT) alternative hypothesis, both of which allow for the intertemporal non-separability of preferences in the sense that past consumption of
Makoto Ohta, Yoshitsugu Kitazawa
core
Mechanisms of IgE‐mediated food allergy and the role of allergen‐specific B cells
FEBS Letters, EarlyView.Food allergy arises when allergen‐specific B cells preferentially produce immunoglobulin E (IgE) antibodies against harmless foods. This article explains the mechanisms driving IgE‐mediated reactions, highlights the central role of these B cells, and discusses how natural tolerance (NT) and oral immunotherapy (OIT) can reshape allergic immune responses.
Juan‐Felipe López +2 more
wiley +1 more source
White matter hyperintensities and Alzheimer's disease: An alternative view of an alternative hypothesis. [PDF]
Alzheimers Dement, 2023 Brickman AM, Rizvi B.
europepmc +1 more source
Bootstrap inference on Fully Modified Estimates of Cointegrating Coefficients: A Comment [PDF]
A bootstrap algorithm proposed by Psaradakis (2001) for hypothesis testing in I(1) regressions is discussed and shown to be valid only under the null hypothesis.
Stefano Fachin
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source