Results 51 to 60 of about 1,000,812 (307)

Composite indices, alternative weights, and comparison robustness [PDF]

Social Choice and Welfare, 2018
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Suman Seth, Mark McGillivray
openaire   +4 more sources

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

Archachatina marginata slime extract predisposes to oxidative stress following sub-acute oral exposure in rats

Beni-Suef University Journal of Basic and Applied Sciences
Background Archachatina marginata, the giant African land snail, is a terrestrial mollusk native to West Africa and commonly found in Nigeria and other tropical regions.
Morayo Barnabas, Damilare Rotimi, Tobiloba Maduakolam-Aniobi, Amarachi Iroaganachi, Funmilayo Okeniyi, Oluwakemi Awakan, Oluyomi Adeyemi   +6 more
doaj   +1 more source

Optimization of Deep Learning Precipitation Models Using Categorical Binary Metrics

Journal of Advances in Modeling Earth Systems, 2020
This work introduces a methodology for optimizing neural network models using a combination of continuous and categorical binary indices in the context of precipitation forecasting.
Pablo R. Larraondo, Luigi J. Renzullo, Albert I. J. M. Van Dijk, Inaki Inza, Jose A. Lozano   +4 more
doaj   +1 more source

Comparison of Leaf Reflectance of Sorghum Plants Infested by Sugarcane Aphids [PDF]

, 2018
Sugarcane aphid, Melanaphis sacchari (Homiptera: Aphididae; Fig. 1A), is a significant pest to sorghum, Sorghum bicolor (Fig. 1B). Sorghum fields are regularly surveyed to detect pest infestation.
Bhattarai, Ganesh P., Dick, Nathaniel, McCornack, Brian   +2 more
core  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Are the welfare losses from imperfect targeting important? [PDF]

The authors evaluate the size of the welfare losses from using alternative “imperfect” welfare indicators as substitutes for the conventionally preferred consumption indicator.
Coady, David P., Skoufias, Emmanuel
core   +3 more sources

Assessment of RGB Vegetation Indices to Estimate Chlorophyll Content in Sugar Beet Leaves in the Final Cultivation Stage

AgriEngineering, 2020
Estimation of chlorophyll content with portable meters is an easy way to quantify crop nitrogen status in sugar beet leaves. In this work, an alternative for chlorophyll content estimation using RGB-only vegetation indices has been explored.
Luis Fernando Sánchez-Sastre, Nuno M. S. Alte da Veiga, Norlan Miguel Ruiz-Potosme, Paula Carrión-Prieto, José Luis Marcos-Robles, Luis Manuel Navas-Gracia, Pablo Martín-Ramos   +6 more
doaj   +1 more source