Results 51 to 60 of about 3,535,535 (212)

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Soundscape Indices: New Features for Classifying Beehive Audio Samples

open access: yesSociobiology, 2020
As the study of honey bee health has gained attention in the biology community, researchers have looked for new, non-invasive methods to monitor the health status of the colony.
Muhammad Zahid Sharif   +4 more
doaj   +1 more source

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

open access: yesFEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang   +4 more
wiley   +1 more source

Power indices in large voting bodies [PDF]

open access: yes, 2010
There is no consensus on the properties of voting power indices when there are a large number of voters in a weighted voting body. On the one hand, in some real-world cases that have been studied the power indices have been found to be nearly ...
Leech, Dennis
core  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

open access: yesFEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang   +2 more
wiley   +1 more source

Optimization of Deep Learning Precipitation Models Using Categorical Binary Metrics

open access: yesJournal of Advances in Modeling Earth Systems, 2020
This work introduces a methodology for optimizing neural network models using a combination of continuous and categorical binary indices in the context of precipitation forecasting.
Pablo R. Larraondo   +4 more
doaj   +1 more source

Measuring polarization by reduced-form indices [PDF]

open access: yes
An abbreviated or reduced-form monotonic polarization index is an increasing function of the between-group term and a decreasing function of the within-group term of a population subgroup decomposable inequality index.
Bhargav Maharaj, Satya R. Chakravarty
core  

Fit indices of the hypothesized and alternative models.

open access: yes, 2015
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Xuji Jia (713996)   +4 more
core   +1 more source

Structural and biochemical analysis of a B12 superbinder

open access: yesFEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices   +3 more
wiley   +1 more source

The 2nd Global Alternative Finance Market Benchmarking Report [PDF]

open access: yes, 2021
The 2nd Global Alternative Finance Market Benchmarking Report contributes 2019 and 2020 data, collected from financial technology firms that undertake digital lending and digital capital raising activities, to our globally comparable panel database on ...
Zhang, Bryan   +12 more
core  

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