Results 241 to 250 of about 4,659,127 (281)

Autophagosome marker, LC3, is released extracellularly via several distinct pathways

open access: yesFEBS Open Bio, EarlyView.
This study establishes a novel HiBiT‐tagging system for ultrasensitive detection of LC3, revealing multiple pathways for its extracellular secretion. It demonstrates that LC3 is released via both autophagy‐dependent and ‐independent mechanisms, including a novel route for nonlipidated LC3‐I.
Koki Saito   +3 more
wiley   +1 more source

Analysis of Treacher Collins syndrome 4‐associated mutations in Schizosaccharomyces pombe

open access: yesFEBS Open Bio, EarlyView.
Fission yeast models carrying Treacher Collins syndrome type 4‐associated mutations reveal that impaired processivity of RNA polymerase I leads to defective rRNA transcription. This study highlights the essential role of a conserved arginine residue in Pol I elongation and provides mechanistic insight into the pathogenesis of ribosomopathies.
Kei Kawakami, Hiroaki Kato
wiley   +1 more source

Hands‐on protocol for preparing water‐soluble fractions from agri‐food samples for NMR‐based metabolomics analysis

open access: yesFEBS Open Bio, EarlyView.
This research protocol outlines a workflow for nuclear magnetic resonance (NMR)‐based metabolomics in the agri‐food sector. Using two case studies—strawberry leaves (solid matrix) and wine (liquid matrix)—it details the procedures for sample preparation, data acquisition, and processing.
Andrea Fernández‐Veloso   +4 more
wiley   +1 more source

DDX3X induces mesenchymal transition of endothelial cells by disrupting BMPR2 signaling

open access: yesFEBS Open Bio, EarlyView.
Elevated DDX3X expression led to downregulation of BMPR2, a key regulator of endothelial homeostasis and function. Our co‐immunoprecipitation assays further demonstrated a molecular interaction between DDX3X and BMPR2. Notably, DDX3X promoted lysosomal degradation of BMPR2, thereby impairing its downstream signaling and facilitating endothelial‐to ...
Yu Zhang   +7 more
wiley   +1 more source

Measuring the Impact of Research Using Conventional and Alternative Metrics

American Journal of Physical Medicine & Rehabilitation, 2019
Bibliometrics use statistical methods to measure the scholarly impact of publications. Bibliometrics are categorized as conventional metrics or alternative metrics.
Sasha E. Knowlton   +8 more
semanticscholar   +1 more source

Alternative metrics in scientometrics: a meta-analysis of research into three altmetrics

Scientometrics, 2014
Alternative metrics are currently one of the most popular research topics in scientometric research. This paper provides an overview of research into three of the most important altmetrics: microblogging (Twitter), online reference managers (Mendeley and
L. Bornmann
semanticscholar   +1 more source

How well developed are altmetrics? A cross-disciplinary analysis of the presence of ‘alternative metrics’ in scientific publications

Scientometrics, 2014
In this paper an analysis of the presence and possibilities of altmetrics for bibliometric and performance analysis is carried out. Using the web based tool Impact Story, we collected metrics for 20,000 random publications from the Web of Science.
Zohreh Zahedi, R. Costas, P. Wouters
semanticscholar   +1 more source

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