Results 51 to 60 of about 786,469 (327)

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

open access: yesFEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia   +5 more
wiley   +1 more source

Preprints in Scholarly Communication: Re-Imagining Metrics and Infrastructures

open access: yesPublications, 2019
Digital scholarship and electronic publishing among the scholarly communities are changing when metrics and open infrastructures take centre stage for measuring research impact.
B. Preedip Balaji, M. Dhanamjaya
doaj   +1 more source

Universal metrics for predicting the activity of a wide range of fuel-cell catalysts

open access: yesScience and Technology of Advanced Materials: Methods, 2023
The increasing demand for universal metrics in material development, particularly in the context of material informatics (MI), emphasises the need for catalytic activity metrics in fuel-cell research, specifically for the oxygen reduction reaction (ORR).
Ganesan Elumalai, Satoshi Tominaka
doaj   +1 more source

Stationary Axion/Dilaton Solutions and Supersymmetry [PDF]

open access: yes, 1996
We present a new set of supersymmetric stationary solutions of pure N=4,d=4 supergravity (and, hence, of low-energy effective string theory) that generalize (and include) the Israel-Wilson-Perj\'es solutions of Einstein-Maxwell theory. All solutions have
Bergshoeff, E., Kallosh, R., Ortin, T.
core   +5 more sources

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

open access: yesFEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer   +7 more
wiley   +1 more source

On t-Conorm Based Fuzzy (Pseudo)metrics

open access: yesAxioms, 2020
We present an alternative approach to the concept of a fuzzy (pseudo)metric using t-conorms instead of t-norms and call them t-conorm based fuzzy (pseudo)metrics or just CB-fuzzy (pseudo)metrics.
Olga Grigorenko   +3 more
doaj   +1 more source

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

open access: yesFEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur   +5 more
wiley   +1 more source

An evaluation of intrusive instrumental intelligibility metrics

open access: yes, 2018
Instrumental intelligibility metrics are commonly used as an alternative to listening tests. This paper evaluates 12 monaural intrusive intelligibility metrics: SII, HEGP, CSII, HASPI, NCM, QSTI, STOI, ESTOI, MIKNN, SIMI, SIIB, and $\text{sEPSM}^\text ...
Hendriks, Richard C.   +2 more
core   +1 more source

Organoids in pediatric cancer research

open access: yesFEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Metrics Toolkit: an online evidence-based resource for navigating the research metrics landscape

open access: yesJournal of the Medical Library Association, 2018
While research metrics may seem well established in the scholarly landscape, it can be challenging to understand how they should be used and how they are calculated.
Robin Champieux   +3 more
doaj   +1 more source

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