Results 131 to 140 of about 2,523,009 (328)
Scientific birds of a feather flock together: science communication on social media rarely happens across or beyond disciplinary boundaries [PDF]
, 2017 The success of academic research in reaching out beyond its own scientific community is a perennial concern, even more so following the rapid adoption of social media and the ability to easily transmit information to potentially millions of people ...
Ahn, Yong-Yeol +2 more
core
Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting
Molecular Oncology, EarlyView.CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia +9 more
wiley +1 more source
Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway
Molecular Oncology, EarlyView.Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed +10 more
wiley +1 more source
Scaling Social Movements Through Social Media: The Case of Black Lives Matter
Social Media + Society, 2018 In this article, we explore the potential role of social media in helping movements expand and/or strengthen themselves internally, processes we refer to as scaling up .
Marcia Mundt +2 more
doaj +1 more source
Social media, alternative metrics and inborn errors of metabolism [PDF]
Journal of Inherited Metabolic Disease, 2020 James, Nurse, Eva, Morava
openaire +2 more sources
An Investigation into the Role of Social Media Marketing in Organisational Performance [PDF]
, 2016 Purpose: In an era that is characterised by speed and ruled by technology, new communication tools are required to achieve business objectives in a fast and innovative manner. This is facilitated by the emergence of Web 2.0 tools.
Barakat, Bassam, DALZIEL, Nurdilek
core
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
From Inside the Rhizome: Mapping the Greek Alternative Mediascape
International Journal of Communication, 2019 We use the rhizome metaphor to approach the highly elusive and contingent field of alternative media. We explore the multiplicity of alternative media practices employed by diverse social actors, critically reflecting on the rhizome’s capacity to foster
Pantelis Vatikiotis, Dimitra L. Milioni
doaj +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells
Molecular Oncology, EarlyView.Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son +13 more
wiley +1 more source