Results 191 to 200 of about 165,714 (266)

H2S‐Releasing Aspirin Nanoparticles Alleviate Endometriosis and Associated Anxiety

Advanced Science, EarlyView.
Albumin nanoparticles loaded with an H2S‐releasing aspirin derivative (ACS14) hitchhiking neutrophils after intraperitoneal injection and preferentially accumulate in endometriosis lesions in mice. The treatment suppresses lesion growth by regulating PI3K/Akt and reduces inflammation by inhibiting NF‐κB.
Mengni Zhou, Renbin Dou, Rong Wu, Yunyu Xu, Ying Wang, Peng Wang, Jinfu Li, Pengcheng Lu, Yu Mao, Jieying Qian, Yunjiao Zhang, Jiqian Zhang, Shasha Zhu   +12 more
wiley   +1 more source

Hepatocyte BDNF Acts as a Novel Immune Checkpoint to Restrain TLR4‐Mediated Acute Hepatitis

Advanced Science, EarlyView.
This study identifies hepatocyte‐derived BDNF as an endogenous TLR4 antagonist that alleviates acute hepatitis. BDNF is downregulated in hepatocytes via REST‐mediated transcriptional repression during ALI/ALF. Mechanistically, BDNF binds to TLR4 on macrophages to suppress inflammation.
Weiwei Zhu, Yaqian Cui, Yongqiang Zhou, Yihui Zheng, Lijiang Huang, Leiming Jin, Qianhui Zhang, Pan Chen, Mengsha Lin, Jiaxi Ye, Yongqiang Xiong, Joo Young Huh, Xiang Hu, Xiaokun Li, Wu Luo, Guang Liang   +15 more
wiley   +1 more source

Timing of Whole Lung Lavage in Autoimmune Pulmonary Alveolar Proteinosis with Concurrent Opportunistic Infection: A Case Report and Systematic Review. [PDF]

Infect Drug Resist
Pu J, Zhou Y, Zhou H, Tang Y, Yu H, He JQ.   +5 more
europepmc   +1 more source

Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization

Advanced Science, EarlyView.
ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo, Fangzhi Lou, Peiran Yang, Yu Zhang, Li Yan, Yunmei Dong, Bing Yang, Haiyang Wang, Yiyun Liu, Juncai Pu, Richard D. Cannon, Peng Xie, Ping Ji, Xin Jin   +13 more
wiley   +1 more source

Association Between Ferritinophagy and M1 Macrophage Polarization During the Acute Phase of Childhood Allergic Asthma. [PDF]

J Inflamm Res
Li J, Wang X, Shi X, Jiang Y, Shen R.
europepmc   +1 more source

Research Progress of Interstitial Lung Disease Based on Single-Cell Sequencing Technology. [PDF]

Can Respir J
Li S, Zhou T, Zhang J, Zhang L, Li Q, Li B, Dai J, Yu R, Li Y, Li S.   +9 more
europepmc   +1 more source

A review of pulmonary development and neonatal interstitial lung disease in dogs and cats from a pathology perspective. [PDF]

J Vet Diagn Invest
Tsoi MF.
europepmc   +1 more source

Skeletal and Dental-Alveolar Changes With Invisalign First Expansion System in the Mixed Dentition: A Retrospective Study. [PDF]

Orthod Craniofac Res
Wang Q, Wang C, Chen Y, Fu Y, Shi J.
europepmc   +1 more source

An automated morphometric approach to evaluate distal lung patterning in mouse models of bronchopulmonary dysplasia. [PDF]

PLoS One
Gainer DJ, Ormiston ML.
europepmc   +1 more source