Results 1 to 10 of about 19 (19)

Rapid Serological Detection of Anti‐GM‐CSF Autoantibodies in Autoimmune Pulmonary Alveolar Proteinosis Using a Novel Immunochromatographic Test

Respirology, Volume 31, Issue 2, Page 184-192, February 2026.
We developed a novel ICT with high clinical performance that can distinguish APAP patients from those with other pulmonary diseases. The rapid and simple detection of GMAbs in serum provided a new practical method for the diagnosis of APAP. See related editorial ABSTRACT Background and Objectives Anti‐GM‐CSF autoantibodies (GMAbs) are essential ...
Chika Narita, Kenjiro Shima, Jun‐ichiro Sekiguchi, Yasuyuki Ozeki, Makoto Akiwa, Shohei Koike, Sachiko Yuki, Keiichi Akasaka, Toshiaki Kikuchi, Nobutaka Kitamura, Koh Nakata   +10 more
wiley   +1 more source

Pulmonary Alveolar Proteinosis Complicated by Invasive Streptococcus pneumoniae Infection Requiring Extracorporeal Membrane Oxygenation: A Case Report

Acute Medicine &Surgery, Volume 13, Issue 1, January/December 2026.
A rare case of autoimmune pulmonary alveolar proteinosis complicated by invasive Streptococcus pneumoniae infection was successfully managed with veno‐venous ECMO. ECMO enabled timely whole lung lavage during recovery from septic shock, which yielded atypical yellowish‐brown fluid likely reflecting infection and led to clinical improvement.
Utaho Mizusawa, Shinichiro Ohshimo, Kazuya Kikutani, Momoko Nakamura, Mitsuaki Nishikimi, Takeshi Namba, Yuki Masuka, Takahiro Inagawa, Nobuaki Shime   +8 more
wiley   +1 more source

Immune activation and response dynamics of human iPSC‐derived macrophages in tuberculosis infection models

Clinical &Translational Immunology, Volume 15, Issue 1, 2026.
In this study, we analysed the immune responses of blood‐derived monocyte macrophages and iPSC‐derived macrophages following BCG/HKMT infection. We found that iPSC‐derived macrophages displayed a markedly stronger activation profile, including faster migration, increased reactive oxygen species production, elevated apoptosis marker expression and ...
Daniela Paasch, Hannah Schevel, Andrea Riehle, Bibiana Costa, Hassan Toufaili, Tabea Gehnen, Julia Dahlmann, Andreas Pavlou, Anna‐Lena Neehus, Ariane Hai Ha Nguyen, Erika Schiering, Theresa Buchegger, Jacinta Bustamante, Gesine Hansen, Ulrich Kalinke, Erich Gulbins, Heike Grassmé, Nico Lachmann   +17 more
wiley   +1 more source

Comparative evaluation of supervised and unsupervised deep learning strategies for denoising hyperpolarized 129Xe lung MRI

Magnetic Resonance in Medicine, Volume 95, Issue 1, Page 138-156, January 2026.
Abstract Purpose Reduced signal‐to‐noise ratio (SNR) in hyperpolarized 129Xe MR images can affect accurate quantification for research and diagnostic evaluations. Thus, this study explores the application of supervised deep learning (DL) denoising, traditional (Trad) and Noise2Noise (N2N) and unsupervised Noise2void (N2V) approaches for 129Xe MR ...
Abdullah S. Bdaiwi, Matthew M. Willmering, Riaz Hussain, Erik Hysinger, Jason C. Woods, Laura L. Walkup, Zackary I. Cleveland   +6 more
wiley   +1 more source

A Rare Case of Pulmonary Alveolar Proteinosis Superimposed by Severe COVID‐19 Pneumonia: Case Report

Respirology Case Reports, Volume 14, Issue 1, January 2026.
This report presents a rare case of pulmonary alveolar proteinosis (PAP) in a young male who subsequently developed COVID‐19. It highlights the critical importance of integrating clinical and radiological precision in diagnosing lung diseases with overlapping imaging features and underscores the rapid deterioration observed when PAP is complicated by ...
Zeinab El Mawla, Jida Al Mulki, Mahmoud Hassoun   +2 more
wiley   +1 more source

Long‐term outcome after allogeneic stem cell transplantation for GATA2 deficiency: An analysis of 67 adults and children from France and Belgium

British Journal of Haematology, Volume 208, Issue 1, Page 250-258, January 2026.
The overall survival of patients receiving an allogeneic haematopoietic stem cell transplant (HSCT) for GATA2 deficiency was significantly better if they were transplanted recently, with a bone marrow or cord blood graft and if the transplant was performed before the onset of excess blast. Excess blast before HSCT was the only factor associated with an
Flore Sicre de Fontbrune, Florian Chevillon, Mony Fahd, Kristell Desseaux, Xavier Poiré, Edouard Forcade, Arthur Sterin, Bénédicte Neven, Virginie Gandemer, Sylvain Thepot, Alice Garnier, Bruno Lioure, Ambroise Marcais, Stephanie Nguyen‐Quoc, Suzanne Tavitian, Laure Vincent, Jean Donadieu, Matthieu Resche Riggon, Sylvie Chevret, Marlene Pasquet, Regis Peffault de Latour   +20 more
wiley   +1 more source

Molecular Investigation in Early‐Onset Interstitial Lung Disease: Results From 699 Unrelated Patients

Respirology, Volume 31, Issue 1, Page 53-61, January 2026.
ABSTRACT Background and Objective Interstitial lung diseases (ILDs) are rare and severe respiratory conditions that may ultimately result in pulmonary fibrosis (PF). The objective of this study was to present the results of molecular diagnosis of early‐onset ILD (from neonates to young adults < 50 years) in a reference genetic diagnostic laboratory ...
Camille Louvrier, Nadia Nathan, Vincent Cottin, Tifenn Desroziers, Valérie Nau, Yohan Soreze, Florence Dastot‐Le Moal, Philippe Reix, Diane Bouvry, Caroline Thumerelle, Martine Reynaud‐Gaubert, Alice Hadchouel, Grégoire Prévot, Effrosyni Manali, Caroline Kannengiesser, Ibrahima Ba, Serge Amselem, Véronique Houdouin, Raphaël Borie, Marie Legendre, on behalf of RespiRare and OrphaLung   +20 more
wiley   +1 more source

Beyond Infection and Lupus Flare: MPO‐ANCA Microscopic Polyangiitis Causing Diffuse Alveolar Hemorrhage in a Patient With Systemic Lupus Erythematosus

Clinical Case Reports, Volume 13, Issue 12, December 2025.
CT of the Chest demonstrated bilateral ground‐glass opacities. ABSTRACT We describe an elderly woman with systemic lupus erythematosus (SLE) who presented with dyspnoea, anemia, and bilateral pulmonary infiltrates initially diagnosed as community‐acquired pneumonia.
Abu Bocus, Tamer Mohamed Zaalouk, Partha Chowdhury, Siraj Nasim   +3 more
wiley   +1 more source

A Hereditary Pulmonary Alveolar Proteinosis Caused by a Novel Hemizygous Variation of the CSF2RA Gene Case Report and Literature Review

Molecular Genetics &Genomic Medicine, Volume 13, Issue 12, December 2025.
This paper describe a 3‐year‐old girl with Turner syndrome who presented with recurrent cough and dyspnea and was diagnosed with hereditary PAP. Genetic analysis revealed a novel hemizygous mutation in the CSF2RA gene (NM_000402.4:c.200_204del, p.Asn67SerfsTer8), which was confirmed as a de novo pathogenic variant and had not been reported previously ...
Qiang Chen, Sufen Zhang, Xiaomin Zhu, Yaru Zhu, Jinyang Chen, Hongjun Chen, Gefei Xiao   +6 more
wiley   +1 more source

Epithelial–Mesenchymal Transition in Human Alveolar Cells Exposed to Indium Chloride

Journal of Applied Toxicology, Volume 45, Issue 11, Page 2353-2362, November 2025.
ABSTRACT For workers in the industry, occupational exposure to indium compounds induces pulmonary disorders, such as interstitial pneumonia. Moreover, lung cancer has been reported in both humans and rodents exposed to indium compounds by inhalation. However, the biological mechanism underlying indium‐induced disorders is poorly understood.
Eiki Kimura, Sharif Ahmed, Haijiao Chen, Yusuke Hiraku   +3 more
wiley   +1 more source