Pulmonary Hypertension and Other Potentially Fatal Pulmonary Complications in Systemic Juvenile Idiopathic Arthritis [PDF]
Objective Systemic juvenile idiopathic arthritis (JIA) is characterized by fevers, rash, and arthritis, for which interleukin‐1 (IL‐1) and IL‐6 inhibitors appear to be effective treatments.
Carol A. Wallace +19 more
core +1 more source
Can somatic GATA2 mutation mimic germ line GATA2 mutation? [PDF]
Somatic GATA2 mutation is associated with immunodeficiency and pulmonary alveolar proteinosis in a patient with myeloproliferative ...
Collin, M +7 more
core
Pleural innate response activator B cells protect against pneumonia via a GM-CSF-IgM axis [PDF]
Pneumonia is a major cause of mortality worldwide and a serious problem in critical care medicine, but the immunophysiological processes that confer either protection or morbidity are not completely understood. We show that in response to lung infection,
Ali, Muhammad +13 more
core +1 more source
Imatinib-induced interstitial pneumonitis – a literature review and case report [PDF]
Imatinib is generally well tolerated, with mild common side effects such as nausea and vomiting, diarrhea, muscle cramps, fatigue, skin rash and edema; however, pulmonary complications are uncommon. A 73-year-old woman undergoing one month treatment with
Ciulei, George +12 more
core +2 more sources
Early IL‐1 Inhibition in Still's Disease: A Window of Opportunity for Improving Outcomes
Objective Still's disease is a complex, multisystemic disorder requiring prompt diagnosis and treatment. This study provides a general assessment of a Still's disease cohort aiming to evaluate the efficacy of early intervention with interleukin‐1 inhibitors (IL‐1i) in achieving clinical inactive disease (CID) and reducing glucocorticoid use in patients
Sara Bindoli +5 more
wiley +1 more source
Lung Lavage Cell Profiles in Diffuse Lung Disease [PDF]
The standard armamentarium of tests that are used by pulmonologist are laboratory tests, pulmonary function tests, different radiological techniques (conventional chest-X rays, HRCT scans, etc) and pathohistological analyses of biopsies.
Silvana Smojver-Ježek +1 more
core +1 more source
Insuficiencia respiratoria neonatal asociada a mutación en el gen de la proteína C del surfactante [PDF]
La insuficiencia respiratoria en el recién nacido a término durante las primeras semanas de vida extrauterina es una situación poco frecuente. Entre sus causas se incluyen las enfermedades difusas del intersticio pulmonar, un grupo heterogéneo de ...
Alava, E. (Enrique) de +4 more
core +1 more source
The Paradox of Metachronous Lipoid Pneumonia
This is a case of recurrent exogenous lipoid pneumonia in a single patient caused by multiple unrelated substances. This case underscores the diagnostic value of radiologic patterns, the significance of meticulous exposure history, and the necessity of contemplating alternative aetiologies in patients with new infiltrates during cancer therapy ...
Haruki Kobayashi
wiley +1 more source
Pulmonary alveolar proteinosis: a rare pulmonary toxicity of sirolimus. [PDF]
Transpl Int. 2007 Mar;20(3):291-6. Pulmonary alveolar proteinosis: a rare pulmonary toxicity of sirolimus. Pedroso SL, Martins LS, Sousa S, Reis A, Dias L, Henriques AC, Sarmento AM, Cabrita A.
CABRITA, A. +7 more
core +1 more source
Macrophages: Subtypes, Distribution, Polarization, Immunomodulatory Functions, and Therapeutics
Macrophages originate from the yolk sac, fetal liver, and bone marrow, differentiating into two main subtypes: M1‐like (proinflammatory) and M2‐like (anti‐inflammatory). These subtypes exhibit high plasticity, allowing them to transform in response to environmental cues or therapeutic interventions.
Mengyuan Peng +10 more
wiley +1 more source

