Alveolar macrophages develop from fetal monocytes that differentiate into long-lived cells in the first week of life via GM-CSF [PDF]
Tissue-resident macrophages can develop from circulating adult monocytes or from primitive yolk sac-derived macrophages. The precise ontogeny of alveolar macrophages (AMFs) is unknown. By performing BrdU labeling and parabiosis experiments in adult mice,
De Kleer, Ismé +9 more
core +2 more sources
Human Inborn Errors of Immunity: 2019 Update of the IUIS Phenotypical Classification. [PDF]
Since 2013, the International Union of Immunological Societies (IUIS) expert committee (EC) on Inborn Errors of Immunity (IEI) has published an updated phenotypic classification of IEI, which accompanies and complements their genotypic classification ...
Ailal, Fatima +18 more
core
Proceedings: Regenerative Medicine for Lung Diseases: A CIRM Workshop Report. [PDF]
The mission of the California Institute of Regenerative Medicine (CIRM) is to accelerate treatments to patients with unmet medical needs. In September 2016, CIRM sponsored a workshop held at the University of California, Los Angeles, to discuss ...
DeWitt, Natalie D +2 more
core +1 more source
Lavagem pulmonar total â A propósito de quatro casos de proteinose alveolar
Resumo: A lavagem pulmonar é uma técnica desenvolvida na década de 60 do século xx com o intuito de remoção fÃsica de material proteináceo dos brônquios, em doentes com proteinose alveolar, levando a uma melhoria clÃnica e funcional. A técnica
M. Aguiar +6 more
doaj +1 more source
In Lysinuric Protein Intolerance system y+L activity is defective in monocytes and in GM-CSF-differentiated macrophages [PDF]
In the recessive aminoaciduria Lysinuric Protein Intolerance (LPI), mutations of SLC7A7/y+LAT1 impair system y+L transport activity for cationic amino acids.
Amelia Barilli +10 more
core +1 more source
Pulmonary Alveolar Proteinosis in an AIDS Patient without Concurrent Pulmonary Infection
Patients with acquired immunodeficiency syndrome (AIDS) are potentially at increased risk for developing secondary pulmonary alveolar proteinosis because of underlying immunosuppression and frequent opportunistic lung infections. This condition. however,
Allen T Liu +4 more
doaj +1 more source
Sirolimus-induced secondary pulmonary alveolar proteinosis
Pulmonary alveolar proteinosis (PAP) is a rare pulmonary syndrome that is characterized by the accumulation of excess surfactant in the alveolar space, leading to impaired gas exchange. Sirolimus-induced PAP is an extremely rare entity that has only been
Stephanie Wang, MD +3 more
doaj +1 more source
Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis [PDF]
Rationale Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP alveolar macrophages are foamy,
Barna, Barbara P +7 more
core +3 more sources
Simultaneous presentation of two noninflammatory lung diseases in an HIV-infected patient
The simultaneous presentation of two noninflammatory pulmonary diseases, pulmonary alveolar proteinosis and Kaposi's sarcoma (Ks), in an HIV-infected patient, is described.
Rafael Martínez-Girón +1 more
doaj +1 more source
Highlights of the Brazilian Thoracic Association guidelines for interstitial lung diseases [PDF]
Interstitial lung diseases (ILDs) are heterogeneous disorders, involving a large number of conditions, the approach to which continues to pose an enormous challenge for pulmonologists.
Aidé, Miguel Abidon +24 more
core +3 more sources

