Results 41 to 50 of about 8,659 (112)

Stat-6 signaling pathway and not Interleukin-1 mediates multi-walled carbon nanotube-induced lung fibrosis in mice: insights from an adverse outcome pathway framework [PDF]

, 2017
Background The accumulation of MWCNTs in the lung environment leads to inflammation and the development of disease similar to pulmonary fibrosis in rodents.
Banville, Allyson, Goodwin, Laura Rose, Halappanavar, Sabina, Nikota, Jake, Vogel, Ulla Birgitte, Wallin, Hakan, Williams, Andrew, Wu, Dongmei, Yauk, Carole Lynn   +8 more
core   +1 more source

Aggressive Head and Neck Squamous Cell Carcinoma in the Setting of GATA2 Deficiency

Head &Neck, Volume 47, Issue 7, Page E82-E86, July 2025.
ABSTRACT Background GATA2 deficiency is a rare genetic disorder associated with hematologic, infectious, and neoplastic complications. We report a case of a patient with GATA2 deficiency who developed aggressive squamous cell carcinoma (SCC) of the head and neck, an atypical manifestation of this condition.
Brejjette Aljabi, James A. Stewart, Kirk Withrow, Carissa M. Thomas   +3 more
wiley   +1 more source

Niche signals and transcription factors involved in tissue-resident macrophage development [PDF]

, 2018
Tissue-resident macrophages form an essential part of the first line of defense in all tissues of the body. Next to their immunological role, they play an important role in maintaining tissue homeostasis. Recently, it was shown that they are primarily of
Bonnardel, Johnny, Guilliams, Martin, T'Jonck, Wouter   +2 more
core   +2 more sources

Silicosis Mimicking Lung Malignancy: A Case Series

Respirology Case Reports, Volume 13, Issue 7, July 2025.
This case series describes three patients that were suspected to have a primary lung malignancy based on FDG‐PET findings, but were found to have pulmonary silicosis. With this series, we demonstrate how histologic examination can differentiate between silicosis and malignancy and provide suggestions to help clinicians differentiate between these two ...
Titia van Duin, Carmen Ambarus, Wouter van Es, Sophie van der Mark, Franz Schramel   +4 more
wiley   +1 more source

CLINICAL APPLICABILITY OF PROPOSED ALGORITHM FOR IDENTIFYING INDIVIDUALS AT RISK FOR HEREDITARY HEMATOLOGIC MALIGNANCIES [PDF]

, 2017
Over the past decade, more than 12 genes have been identified to cause hereditary predispositions to hematologic malignancies. These syndromes are characterized by an increased risk to develop myelodysplastic syndrome (MDS), acute myeloid leukemia (AML),
Clifford, Maggie
core   +1 more source

Telomere Shortening in Interstitial Lung Disease: Challenges and Promises

The Clinical Respiratory Journal, Volume 19, Issue 7, July 2025.
Telomerase abnormalities such as related gene mutations lead to decrease in telomerase activity and telomere shortening. Individual cells undergoing continuous division exhibit telomere shortening. A successive shortening of the telomere results in dysfunctional telomeres.
Haonan Jin, Jiamin Song, Ronglin Gao, Bingxian Sha, Shengyuan Wang, Peiming Luo, Li Yu, Xianghuai Xu, Xuan Wang   +8 more
wiley   +1 more source

Phase 1b randomized, double-blind study of namilumab, an anti-granulocyte macrophage colony-stimulating factor monoclonal antibody, in mild-to-moderate rheumatoid arthritis [PDF]

, 2017
Change from baseline in swollen (a) and tender (b) joint counts. *Error bars show upper SE for placebo and lower SE for namilumab. SE standard error, SJC swollen joint count, TJC tender joint count.
A. Batalov, AD Cook, AD Cook, AD Cook, AE Nieuwenhuijze van, AJ Fleetwood, AK Ulfgren, AM Gestel van, B. Souberbielle, BC Trapnell, BC Trapnell, BP Hazenberg, C Fiehn, C Plater-Zyberk, CQ Chu, D. Saurigny, DL Scott, E. Esfandiari, E. Lloyd, EGE Vries de, EM Krinner, F Behrens, GR Burmester, GR Burmester, GR Burmester, GR Burmester, GS Firestein, IK Campbell, JA Hamilton, JA Hamilton, JA Hamilton, JC Gasson, JD Griffin, JM Alvaro-Gracia, M Hashimoto, ML Hetland, NJ Zvaifler, R. Stoilov, S Garcia, SA Antoniu, T Kitamura, T Takeuchi, T. W. J. Huizinga, T. Wagner, VA Manivel, W Kievit, W Wang, WD Xu   +47 more
core   +3 more sources

Clinicopathological Challenge: Five Males Presenting With Progressive Skin Thickening and Hoarse Voices

International Journal of Dermatology, Volume 64, Issue 7, Page 1161-1163, July 2025.
ABSTRACT Five male patients, including four siblings and one unrelated child, presented with progressive hoarseness, waxy eyelid papules, mucosal thickening, and skin plaques. Histopathologic analysis revealed PAS‐positive perivascular hyaline deposition, and genetic testing confirmed a homozygous ECM1 mutation in all patients, consistent with lipoid ...
R. Maxwell Regester, Molly Antonson, Nicole N. Harter   +2 more
wiley   +1 more source

Synovial tissue macrophages: friend or foe? [PDF]

, 2017
Healthy synovial tissue includes a lining layer of synovial fibroblasts and macrophages. The influx of leucocytes during active rheumatoid arthritis (RA) includes monocytes that differentiate locally into proinflammatory macrophages, and these produce ...
Alivernini, Stefano, Kurowska-Stolarska, Mariola   +1 more
core   +2 more sources

Update of the list of qualified presumption of safety (QPS) recommended microbiological agents intentionally added to food or feed as notified to EFSA 22: Suitability of taxonomic units notified to EFSA until March 2025

EFSA Journal, Volume 23, Issue 7, July 2025.
Abstract The qualified presumption of safety (QPS) process was developed to assess the safety of microorganisms used in food and feed chains. During the period covered by this Statement, no new information warranted changes to the status of previously recommended QPS taxonomic units.
EFSA Panel on Biological Hazards (BIOHAZ), Ana Allende, Avelino Alvarez‐Ordóñez, Valeria Bortolaia, Sara Bover‐Cid, Alessandra De Cesare, Wietske Dohmen, Laurent Guillier, Liesbeth Jacxsens, Maarten Nauta, Lapo Mughini‐Gras, Jakob Ottoson, Luisa Peixe, Fernando Perez‐Rodriguez, Panagiotis Skandamis, Elisabetta Suffredini, Pier Sandro Cocconcelli, Pablo Salvador Fernández Escámez, Miguel Prieto Maradona, Amparo Querol, Lolke Sijtsma, Juan Evaristo Suarez, Marianne Chemaly, Ingvar Sundh, Fulvio Barizzone, Justine Dastouet, Nadya Doyle, Sandra Correia, Lieve Herman   +28 more
wiley   +1 more source