Results 61 to 70 of about 9,034 (208)

Incidence and classification of pediatric diffuse parenchymal lung diseases in Germany [PDF]

, 2009
Background: Diffuse parenchymal lung diseases (DPLD) in children represent a rare and heterogeneous group of chronic pulmonary disorders. Despite substantial advances in genetics and pathomechanisms, these often lethal diseases are still under-diagnosed.
Matthias Griese, Melanie Haug, Frank Brasch, Achim Freihorst, Peter Lohse, Rüdiger von Kries, Theodor Zimmermann, Dominik Hartl, LL Fan, A Clement, R Dinwiddie, A Clement, American Thoracic Society/European Respiratory Society International Multidisciplinary Consensus Classification of the Idiopathic Interstitial Pneumonias, GH Deutsch, R von Kries, A Laverty, J de Vries, LM Palomar, D Hartl, M Hallman, SE Wert   +20 more
core   +3 more sources

Autoimmune pulmonary alveolar proteinosis in an adolescent successfully treated with inhaled rhGM-CSF (molgramostim)

Respiratory Medicine Case Reports, 2018
Autoimmune pulmonary alveolar proteinosis (aPAP) is a rare parenchymal lung disease characterized by accumulation of surfactant in the airways with high levels of granulocyte-macrophage colony stimulating factor (GM-CSF) antibodies in blood.
Marta E. Gajewska, Sajitha S. Sritharan, Eric Santoni-Rugiu, Elisabeth M. Bendstrup   +3 more
doaj   +1 more source

Can somatic GATA2 mutation mimic germ line GATA2 mutation? [PDF]

, 2018
Somatic GATA2 mutation is associated with immunodeficiency and pulmonary alveolar proteinosis in a patient with myeloproliferative ...
Collin, M, Dickinson, R, Lipman, M, Lowe, D, Marafioti, T, Mitchell, C, Pocock, R, Sekhar, M   +7 more
core  

From the definition of Silicosis at the 1930 Johannesburg conference to the blurred boundaries between pneumoconioses, sarcoidosis and pulmonary alveolar proteinosis (PAP) [PDF]

, 2015
The 1930 International Labour Office Conference on silicosis in Johannesburg identified silicosis by setting a medicolegal framework to its nosology: as with other occupational illnesses, its medical content was fixed under economic pressure.
Catinon, Mickaël, Cavalin, Catherine, Chemarin, Cécile, Rosental, Paul-Andre, Vincent, Michel   +4 more
core   +3 more sources

Immune activation and response dynamics of human iPSC‐derived macrophages in tuberculosis infection models

Clinical &Translational Immunology, Volume 15, Issue 1, 2026.
In this study, we analysed the immune responses of blood‐derived monocyte macrophages and iPSC‐derived macrophages following BCG/HKMT infection. We found that iPSC‐derived macrophages displayed a markedly stronger activation profile, including faster migration, increased reactive oxygen species production, elevated apoptosis marker expression and ...
Daniela Paasch, Hannah Schevel, Andrea Riehle, Bibiana Costa, Hassan Toufaili, Tabea Gehnen, Julia Dahlmann, Andreas Pavlou, Anna‐Lena Neehus, Ariane Hai Ha Nguyen, Erika Schiering, Theresa Buchegger, Jacinta Bustamante, Gesine Hansen, Ulrich Kalinke, Erich Gulbins, Heike Grassmé, Nico Lachmann   +17 more
wiley   +1 more source

Congenital Pulmonary Alveolar Proteinosis

Case Reports in Pediatrics, 2013
Pulmonary alveolar proteinosis (PAP) is a rare syndrome characterized by pulmonary surfactant accumulation within the alveolar spaces. It occurs with a reported prevalence of 0.1 per 100,000 individuals. Two clinically different pediatric types have been
Saber Hammami, Khaled Harrathi, Khaled Lajmi, Samir Hadded, Chebil Ben Meriem, Mohamed Néji Guédiche   +5 more
doaj   +1 more source

Autoimmune pulmonary alveolar proteinosis in children

ERJ Open Research, 2022
In childhood, a multitude of causes lead to pulmonary alveolar proteinosis (PAP), an excessive surfactant accumulation in the alveolar space, limiting gas exchange.
Matthias Griese, Panagiota Panagiotou, Effrosyni D. Manali, Mirjam Stahl, Nicolaus Schwerk, Vanessa Costa, Konstantinos Douros, Maria Kallieri, Ruth Maria Urbantat, Horst von Bernuth, Lykourgos Kolilekas, Lurdes Morais, Ana Ramos, Kerstin Landwehr, Katrin Knoflach, Florian Gothe, Karl Reiter, Vassiliki Papaevangelou, Athanasios G. Kaditis, Christina Kanaka-Gantenbein, Spyros A. Papiris   +20 more
doaj   +1 more source

Comparative evaluation of supervised and unsupervised deep learning strategies for denoising hyperpolarized 129Xe lung MRI

Magnetic Resonance in Medicine, Volume 95, Issue 1, Page 138-156, January 2026.
Abstract Purpose Reduced signal‐to‐noise ratio (SNR) in hyperpolarized 129Xe MR images can affect accurate quantification for research and diagnostic evaluations. Thus, this study explores the application of supervised deep learning (DL) denoising, traditional (Trad) and Noise2Noise (N2N) and unsupervised Noise2void (N2V) approaches for 129Xe MR ...
Abdullah S. Bdaiwi, Matthew M. Willmering, Riaz Hussain, Erik Hysinger, Jason C. Woods, Laura L. Walkup, Zackary I. Cleveland   +6 more
wiley   +1 more source

iPSC-Derived Macrophages Effectively Treat Pulmonary Alveolar Proteinosis in Csf2rb-Deficient Mice

Stem Cell Reports, 2018
Summary: Induced pluripotent stem cell (iPSC)-derived hematopoietic cells represent a highly attractive source for cell and gene therapy. Given the longevity, plasticity, and self-renewal potential of distinct macrophage subpopulations, iPSC-derived ...
Adele Mucci, Elena Lopez-Rodriguez, Miriam Hetzel, Serena Liu, Takuji Suzuki, Christine Happle, Mania Ackermann, Henning Kempf, Roman Hillje, Jessica Kunkiel, Ewa Janosz, Sebastian Brennig, Silke Glage, Jens P. Bankstahl, Sabine Dettmer, Thomas Rodt, Gudrun Gohring, Bruce Trapnell, Gesine Hansen, Cole Trapnell, Lars Knudsen, Nico Lachmann, Thomas Moritz   +22 more
doaj   +1 more source

Insuficiencia respiratoria neonatal asociada a mutación en el gen de la proteína C del surfactante [PDF]

, 2005
La insuficiencia respiratoria en el recién nacido a término durante las primeras semanas de vida extrauterina es una situación poco frecuente. Entre sus causas se incluyen las enfermedades difusas del intersticio pulmonar, un grupo heterogéneo de ...
Alava, E. (Enrique) de, Alzina, V. (Valentín), Bastero, P. (P.), Gaboli, M. (M.), Romero-Montero, A. (A.)   +4 more
core   +1 more source