Development‐based In Vivo Bioreactor Strategy for Challenging Senescent Bone Reconstruction
We present a development‐based in vivo bioreactor strategy to generate rejuvenated bone grafts (vBR‐Bone) within aged hosts. By enclosing vBR‐Bone fragments within an asymmetric biomimetic periosteum, segmental femoral defects in aged mice were successfully repaired within 6 weeks. Mechanistically, the multifactors of vBR‐Bone reconstitute a remodeling
Wenchao Zhang +9 more
wiley +1 more source
Cyclic Strain and Macrophage-Mediated Transport Govern Micron-Sized PM<sub>2</sub>.<sub>5</sub> Translocation across the Air-Blood Barrier. [PDF]
Li Y, Xu J, Gao Z, Chen H.
europepmc +1 more source
Kapoor Shashi, Sood G, Aurora A, Sood M
openaire +2 more sources
ALKBH3 m1A Demethylase Deficiency Reduces Alzheimer's Amyloid‐β Pathology
This study identifies that ALKBH3‐driven m1A demethylation orchestrates Alzheimer's disease progression by disrupting mitochondrial and synaptic homeostasis. This epitranscriptomic mechanism suppresses PINK1‐mediated mitophagy via m1A erasure, leading to mitochondrial dysfunction, oxidative stress, elevated Aβ production, and impaired microglial ...
Yueyang Li +25 more
wiley +1 more source
Daniel Recasens i Ma. Dolors Pallarès (2001): De la fonètica a la fonologia. Les consonants i assimilacions consonàntiques en català, Barcelona, Ariel Practicum, Ariel [PDF]
Fernàndez Planas, Anna Maria
core
Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source
Articulatory-kinematic changes in speech following surgical treatment for oral or oropharyngeal cancer: A systematic review. [PDF]
Tienkamp TB +7 more
europepmc +1 more source
Pulmonary alveolar microlithiasis
Saeed Hoseininia +2 more
openaire +3 more sources
Highly Biomimetic Ectodermal Epithelial Organoids for Epithelial Barrier Stimulation Assays
ABSTRACT Evaluating the potential toxicity of pharmaceuticals and biomaterials to ectodermal epithelia, such as the oral mucosa and skin, is indispensable in pre‐clinical assessments. However, this remains a challenge primarily owing to the lack of physiologically relevant and accurate screening models.
Yiming Chen +13 more
wiley +1 more source
Targeted Lung Premetastasis Niche: Mechanisms, Strategies, and Application. [PDF]
Cao C +12 more
europepmc +1 more source

