Results 221 to 230 of about 2,804 (278)

Amyloid, Crohn's disease, and Alzheimer's disease - are they linked? [PDF]

open access: yesFront Cell Infect Microbiol
Duda-Madej A   +4 more
europepmc   +1 more source

Boosting Sensory Nerve‐to‐Bone Interactions Enhances Hedgehog Mediated Calvarial Bone Repair

open access: yesAdvanced Science, EarlyView.
Boosting sensory nerve activity via TrkA agonism strongly accelerates calvarial bone repair in adult mice. Furthermore, single‐cell RNA sequencing and neuron–bone interactome analyses identify these sensory neurons as a direct neural source of Hedgehog pathway ligands. Consequently, these ligands drive osteoblast differentiation of skeletal progenitors,
Zhao Li   +9 more
wiley   +1 more source

Caveolin‐1 Stabilizes SERCA2 to Counteract Acute Kidney Injury via Suppression of Ca2+‐Dependent Endoplasmic Reticulum Stress in Distal Tubules

open access: yesAdvanced Science, EarlyView.
In AKI, initial kidney injury upregulates the expression of Cav‐1, which subsequently binds to and stabilizes SERCA2 via its scaffolding domain and through deubiquitination, thereby regulating Ca2+ homeostasis and ER stress. Conversely, Cav‐1 deficiency accelerates SERCA2 degradation, triggering Ca2+ overload and ER stress, and ultimately exacerbating ...
Yan Zhang   +19 more
wiley   +1 more source

WTAP‐Mediated m6A Modification Targets the LRP1‐Lipid Metabolism Axis to Regulate Joint Cartilage Regeneration

open access: yesAdvanced Science, EarlyView.
WTAP drives cartilage regeneration by activating an LRP1‐dependent lipid metabolic program in macrophages, enhancing IL‐10 and TGF‐β secretion to promote chondrogenic differentiation. Leveraging this mechanism, virtual screening identifies LRP1‐targeting compounds that effectively stimulate cartilage repair, highlighting a druggable epigenetic ...
Chenyan Huang   +6 more
wiley   +1 more source

El canvi fonètic: lèxic o gradual? [PDF]

open access: yes, 2000
Carrera i Sabaté, Josefina
core  

Aptamer‐Directed Porous DNA Nanocomposite Hydrogel for Active Pulp Preservation: Immunomodulation, Stem Cell Recruitment and Reparative Dentinogenesis

open access: yesAdvanced Science, EarlyView.
This study presents an injectable DNA‐based porous hydrogel integrating catechol motifs and targeting aptamers for pulpitis management. Upon in situ crosslinking, the scaffold actively recruits endogenous dental pulp stem cells, restores redox homeostasis, and modulates immune responses.
Luhui Cai   +9 more
wiley   +1 more source
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Alveolar Distraction

Clinics in Plastic Surgery, 2021
Alveolar distraction osteogenesis (ADO) has been used for the reconstruction of atrophic alveolus for decades. The advantage of this technique is that it augments the bone and soft tissues together, creating a better alveolar platform for subsequent surgeries and dental rehabilitation.
Elçin, Esenlik   +1 more
openaire   +2 more sources

Alveolar adenoma

Human Pathology, 1986
This report describes six cases of an unusual pulmonary neoplasm, the alveolar adenoma, that consists of a benign proliferation of alveolar epithelium and septal mesenchyme. The neoplasm presents as a solitary peripheral lesion on chest radiographs, particularly in older patients.
S A, Yousem, L, Hochholzer
openaire   +2 more sources

Alveolar Adenoma

The Annals of Thoracic Surgery, 2004
Alveolar adenoma of the lung is a rare benign neoplasm with proliferation of alveolar epithelium and septal mesenchyme. This unusual neoplasm presents as a solitary mass on chest roentgenograms, especially in older, asymptomatic patients. We report a case of this unusual neoplasm and describe the histologic and radiographic features of this tumor ...
Matthew S, Hartman   +3 more
openaire   +2 more sources

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