Results 111 to 120 of about 2,471 (170)

HnRNPA2B1 ISGylation Regulates m6A‐Tagged mRNA Selective Export via ALYREF/NXF1 Complex to Foster Breast Cancer Development

Advanced Science
AbstractRegulating nuclear export precisely is essential for maintaining mRNA homeostasis and impacts tumor progression. However, the mechanisms governing nuclear mRNA export remain poorly elucidated. Herein, it is revealed that the enhanced hypoxic long no‐ncoding RNA (lncRNA prostate cancer associated transcript 6 (PCAT6) in breast cancer (BC ...
Ting Jin, Liping Yang, Chao Chang, Haojun Luo, Rui Wang, Yubi Gan, Yan Sun, Yuetong Guo, Rui Tang, Shanchun Chen, Die Meng, Peijin Dai, Manran Liu   +12 more
openaire   +3 more sources

NSUN6-mediated 5-methylcytosine modification of NDRG1 mRNA promotes radioresistance in cervical cancer

Molecular Cancer
Background Radioresistance is the leading cause of death in advanced cervical cancer (CC). Dysregulation of RNA modification has recently emerged as a regulatory mechanism in radiation and drug resistance.
Min Yu, Mengdong Ni, Fei Xu, Chaohua Liu, Lihua Chen, Jiana Li, Siyu Xia, Yixin Diao, Jiaxin Chen, Jun Zhu, Xiaohua Wu, Min Tang, Jiajia Li, Guihao Ke   +13 more
doaj   +1 more source

Exploring the impact of cuproptosis on prostate cancer prognosis via RNA methylation regulation based on single cell and bulk RNA sequencing data [PDF]

BackgroundCuproptosis, along with RNA methylation regulators, has recently come to the fore as innovative mechanisms governing cell death, exerting profound impact on the onset and progression of multiple cancers. Nonetheless, the prognostic implications
Jiaxuan Qin, Jiaxuan Qin, Jiaxuan Qin, Junchao Wu, Junchao Wu, Junchao Wu, Peng Guo, Rongfang Zhong, Song Fan, Song Fan, Song Fan, Wentian Wu, Ziqi Chen, Ziqi Chen, Ziqi Chen   +14 more
core   +1 more source

mRNA export and cancer [PDF]

, 2016
This PhD focuses on the relationship between mRNA export and ...
Cumberbatch, Marcus G
core  

TREX tetramer disruption alters RNA processing necessary for corticogenesis in THOC6 Intellectual Disability Syndrome. [PDF]

THOC6 variants are the genetic basis of autosomal recessive THOC6 Intellectual Disability Syndrome (TIDS). THOC6 is critical for mammalian Transcription Export complex (TREX) tetramer formation, which is composed of four six-subunit THO monomers.
Amiel, Jeanne, Baris, Safa, Berger, Brandon, Bielas, Stephanie L, Boztug, Kaan, Corning, Ken, de Munnik, Sonja, Dmytrus, Jasmin, Girisha, Katta M, Gordon, Christopher T, Hebbar, Malavika, Jimenez-Heredia, Raúl, Johnson, Katherine, Karakoc-Aydiner, Elif, Krolo, Ana, LaForce, Geneva R, Le, Thuy-Linh, Lebel, Robert Roger, Li, Shaokun, Louie, Raymond J, Ozen, Ahmet, Perillo, Delia R, Pfennig, Christian D, Pfundt, Rolph, Prijoles, E J, Regan, Samantha L, Schaffer, Ashleigh E, Shukla, Anju, Srivastava, Anshika, Werren, Elizabeth A   +29 more
core   +1 more source

eLife Assessment: Cryo-EM structure of the CBC-ALYREF complex

, 2023
openaire   +1 more source

P R Health Sci J [PDF]

ObjectiveThe incidence of oral cavity and pharyngeal cancer in Puerto Rican men is higher than it is in the men of any other ethnic/racial group in the United States of America (US). The information regarding the effect of the human papilloma virus (HPV)

core  

The RNA Exosome Adaptor ZFC3H1 Functionally Competes with Nuclear Export Activity to Retain Target Transcripts [PDF]

, 2018
Jensen, Torben Heick, Karadoulama, Evdoxia, Lubas, Michal, Mąkosa, Dawid, Silla, Toomas   +4 more
core   +1 more source

Reviewer #3 (Public Review): Cryo-EM structure of the CBC-ALYREF complex

, 2023
openaire   +1 more source

Emerging roles of RNA N5-methylcytosine modification in reproductive physiology and gynecological diseases. [PDF]

Epigenetics
Lv F, Jin Y, Yu S, Yang X, Xia S, Ye X, Zhao Q, Hu Y, Zheng A, Wu Y, Tong J.   +10 more
europepmc   +1 more source