Results 251 to 260 of about 472,310 (340)

Alzheimer's Disease Neuroimaging Initiative: Two decades of pioneering Alzheimer's disease research and future directions. [PDF]

Alzheimers Dement
Okonkwo OC, Rivera-Mindt M, Weiner MW, Alzheimer's Disease Neuroimaging Initiative.   +3 more
europepmc   +1 more source

Measurement of medial temporal lobe atrophy in diagnosis of Alzheimer's disease

, 1993
Mony J. de Leon, James Golomb, Antonio Convit, Susan DeSanti, ThomasD. Mcrae, Ajax E. George, K Jobst, A. David Smith   +7 more
openalex   +1 more source

Chirality Regulates Stem Cell Fate and Promotes Corneal Epithelial Regeneration via Manipulating Notch Pathway

Advanced Science, EarlyView.
Chirality governs the limbal epithelial stem cell fate. Right‐handed chirality enhances cell proliferation and differentiation, while left‐handed chirality partially maintains cell stemness. By activating the Notch pathway, 3D right‐handed chiral hydrogel offers a drug‐free and cell‐free strategy for effective corneal regeneration.
Shiding Li, Yu Zhao, Junzhao Chen, Beibei Wu, Nianxuan Wu, Hao Sun, Liangbo Chen, Chuanliang Feng, Yao Fu   +8 more
wiley   +1 more source

Study of cytoskeletal proteins in fibroblasts cultured from familial Alzheimer's disease

, 1991
Mamoru Takeda, T. Nishimura, Shiro Hariguchi, Yoshitaka Tatebayashi, Takashi Tanaka, Satoshi Tanimukai, K. Tade   +6 more
openalex   +1 more source

Monitoring the Dynamics of Alzheimer's Disease Biomarkers and the APOE–Tau Axis via Human Cerebral Organoids with Immuno‐SERS

Advanced Science, EarlyView.
Noninvasive and sensitive detection of tau protein dynamics across developmental stages and APOE genotypes remain a challenge in Alzheimer's disease (AD) research. This study reveals the dynamics of tau secretion in label‐free manner using surface‐enhanced Raman spectroscopy (SERS) and human cerebral organoids (hCOs). This study provides novel insights
Yongjae Jo, Youngjun Kim, Rian Kang, Seho Lee, Dang Du Nguyen, Soomin Park, Dongjoon Lee, Jong Won Han, Inhee Mook‐Jung, Luke P. Lee, Jong‐Chan Park, Inki Kim   +11 more
wiley   +1 more source

PRMT3‐Mediated H4R3me2a Promotes Primary Age‐Related Tauopathy by Driving Tau Hyperphosphorylation in Neuron

Advanced Science, EarlyView.
This study identifies PRMT3‐mediated H4R3me2a as a critical driver of tau hyperphosphorylation in primary age‐related tauopathy. Mechanistic insights reveal that the PRMT3/H4R3me2a/miR‐448 axis suppresses IGF1R expression via epigenetic regulation, further dysregulating the PI3K/AKT/GSK3β pathway.
Haotian Liu, Xinnan Liu, Fengyuan Tian, Yashuang Chen, Jingying Li, Xue Wang, Wenying Qiu, Xia Wang, Chao Ma, Wei Ge   +9 more
wiley   +1 more source

Risk Factors for Dementia and Cognitive Decline [PDF]

, 2003
Gilhooly, M, Gow, J
core  

Potassium homeostasis during disease progression of Alzheimer's disease. [PDF]

J Physiol
Samokhina E, Mangat A, Malladi CS, Gyengesi E, Morley JW, Buskila Y.   +5 more
europepmc   +1 more source

Rapamycin Alleviates Heart Failure Caused by Mitochondrial Dysfunction and SERCA Hypoactivity in Syntaxin 12/13 Deficient Models

Advanced Science, EarlyView.
Rapamycin alleviates heart failure via TFEB and CaMKII pathways in Syntaxin 12/13 deficient models. Stx12 deficiency causes heart failure via impaired iron trafficking to mitochondria, reducing respiratory complexes and sarcoplasmic reticulum Ca2+‐ATPase (SERCA).
Run‐Zhou Yang, Fang Li, Jiao Liu, Shu‐Ang Li, Dan‐Hua Liu, Zhuanbin Wu, Pei‐Pei Liu, Wenju Liu, Bin Zhou, Cizhong Jiang, Haibing Zhang, Ying Yu, Jian‐Sheng Kang   +12 more
wiley   +1 more source

Measuring time saved in Alzheimer's disease: What is a meaningful slowing of progression? [PDF]

Alzheimers Dement (N Y)
Lanctot K, Jönsson L, Atri A, Paulsen R, Mattke S, Hahn-Pedersen JH, Polavieja P, Maltesen T, León T, Gustavsson A, Alzheimer's Disease Neuroimaging Initiative.   +10 more
europepmc   +1 more source