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Microglial ApoD‐induced NLRC4 inflammasome activation promotes Alzheimer's disease progression
Animal Models and Experimental Medicine, EarlyView.We found that NLRC4 inflammasome was activated in microglia releasing IL6 and TNF‐α to impair the hippocampal neural stem cells (NSCs) self‐proliferation. ApoD contributed to activating NLRC4 inflammasome in microglia. Targeting the ApoD provides beneficial effects on NSCs self‐proliferation and mature neurons survival.
Yaliang Yu +6 more
wiley +1 more source
Animal Models and Experimental Medicine, EarlyView.Schematic diagram of inverse comorbidities of Alzheimer's disease and lung cancer. Abstract Background Alzheimer's disease (AD) and lung cancer are leading causes of mortality among the older population. Epidemiological evidence suggests an antagonistic relationship between them, whereby patients with AD exhibit a reduced risk of developing cancer and ...
Mingfeng Li +11 more
wiley +1 more source
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Nature Reviews Disease Primers, 2015
Alzheimer's disease is a chronic illness with long preclinical and prodromal phases (20 years) and an average clinical duration of 8-10 years. The disease has an estimated prevalence of 10-30% in the population >65 years of age with an incidence of 1-3%.
Oliver Wirths +2 more
+6 more sources
Alzheimer's disease is a chronic illness with long preclinical and prodromal phases (20 years) and an average clinical duration of 8-10 years. The disease has an estimated prevalence of 10-30% in the population >65 years of age with an incidence of 1-3%.
Oliver Wirths +2 more
+6 more sources
The Lancet, 2016
Although the prevalence of dementia continues to increase worldwide, incidence in the western world might have decreased as a result of better vascular care and improved brain health. Alzheimer's disease, the most prevalent cause of dementia, is still defined by the combined presence of amyloid and tau, but researchers are gradually moving away from ...
Scheltens, Philip +6 more
openaire +4 more sources
Although the prevalence of dementia continues to increase worldwide, incidence in the western world might have decreased as a result of better vascular care and improved brain health. Alzheimer's disease, the most prevalent cause of dementia, is still defined by the combined presence of amyloid and tau, but researchers are gradually moving away from ...
Scheltens, Philip +6 more
openaire +4 more sources
Scientific American, 1985
Significant progress has been made in identifying changes in cholinergic, monoaminergic, and peptidergic neurotransmitter systems in the brains of individuals with Alzheimer's disease. Moreover, neurobiological approaches are beginning to reveal the relationships between these neurotransmitter abnormalities and histological hallmarks of the disease, i ...
D L, Price +2 more
+7 more sources
Significant progress has been made in identifying changes in cholinergic, monoaminergic, and peptidergic neurotransmitter systems in the brains of individuals with Alzheimer's disease. Moreover, neurobiological approaches are beginning to reveal the relationships between these neurotransmitter abnormalities and histological hallmarks of the disease, i ...
D L, Price +2 more
+7 more sources
Current Opinion in Neurobiology, 1996
Our understanding of the etiologies of the Alzheimer diseases is advancing rapidly, led by the discovery of relevant genetic mutations for autosomal-dominant forms of the disease and widespread confirmation of the role played by apolipoprotein E, the major susceptibility gene for the common form of Alzheimer's disease.
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Our understanding of the etiologies of the Alzheimer diseases is advancing rapidly, led by the discovery of relevant genetic mutations for autosomal-dominant forms of the disease and widespread confirmation of the role played by apolipoprotein E, the major susceptibility gene for the common form of Alzheimer's disease.
openaire +3 more sources
The Lancet, 2019
Alzheimer's disease (AD) dementia refers to a particular onset and course of cognitive and functional decline associated with age together with a particular neuropathology. It was first described by Alois Alzheimer in 1906 about a patient whom he first encountered in 1901.
Jose A, Soria Lopez +2 more
openaire +4 more sources
Alzheimer's disease (AD) dementia refers to a particular onset and course of cognitive and functional decline associated with age together with a particular neuropathology. It was first described by Alois Alzheimer in 1906 about a patient whom he first encountered in 1901.
Jose A, Soria Lopez +2 more
openaire +4 more sources
The Lancet, 2006
Alzheimer's disease is the most common cause of dementia. Research advances have enabled detailed understanding of the molecular pathogenesis of the hallmarks of the disease--ie, plaques, composed of amyloid beta (Abeta), and tangles, composed of hyperphosphorylated tau.
Kaj, Blennow +2 more
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Alzheimer's disease is the most common cause of dementia. Research advances have enabled detailed understanding of the molecular pathogenesis of the hallmarks of the disease--ie, plaques, composed of amyloid beta (Abeta), and tangles, composed of hyperphosphorylated tau.
Kaj, Blennow +2 more
openaire +2 more sources
Pharmacogenomics in Alzheimer's Disease
Mini-Reviews in Medicinal Chemistry, 2002Scientists from the EuroEspes Biomedical Research Center, La Coruna, Spain, presented the conclusions of a pharmacogenomics study in Alzheimer's disease at the Sixth International Stockholm/Springfield Symposium on Advances in Alzheimer Therapy, held in Stockholm, April 5-8, 2000.
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Osteoporosis and Alzheimer´s disease (or Alzheimer´s disease and Osteoporosis)
Ageing Research ReviewsAlzheimer's disease (AD) and osteoporosis are two diseases that mainly affect elderly people, with increases in the occurrence of cases due to a longer life expectancy. Several epidemiological studies have shown a reciprocal association between both diseases, finding an increase in incidence of osteoporosis in patients with AD, and a higher burden of ...
Wanionok, Nahuel Ezequiel +2 more
openaire +3 more sources