Results 121 to 130 of about 3,022,233 (266)
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Internet y la capacidad de innovar en América Latina [PDF]
(Disponible en idioma inglés únicamente) En este trabajo presentamos una panorámica general de la situación de internet en América Latina y sostenemos que si bien los países latinoamericanos se han incorporado relativamente tarde, en principio pueden ...
Alberto Chong, Alejandro Micco
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YIPFα1A expression is regulated by multilayered molecular mechanisms
FEBS Open Bio, EarlyView.YIPFα1A, a five‐pass Golgi protein, is regulated at multiple layers. (1) Rare‐codon enrichment drives translation‐coupled mRNA decay. (2) A proximal 3′‐UTR element stabilizes mRNA. (3) A distal 3′‐UTR element included by alternate poly(A) site usage represses translation, which can be overridden by the proximal 3′‐UTR element.
Tokio Takaji +2 more
wiley +1 more source
FEBS Open Bio, EarlyView.The MRP4 transporter exports several drugs and signaling molecules. Here, we identified key promoter elements regulating basal MRP4 expression. Using reporter assays, we defined a conserved region with essential Sp1 and contributory Ets sites, which controlled basal MRP4 expression.
Debora Singer +7 more
wiley +1 more source
Los mercados laborales en América Latina: el argumento de la oferta [PDF]
(Disponible en idioma inglés únicamente) En este trabajo se muestra que los factores que inciden en la oferta laboral fueron determinantes claves de los cambios en el empleo, el desempleo y las diferencias de ingreso en América Latina durante los años 90.
Miguel Székely, Suzanne Duryea
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Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs
FEBS Open Bio, EarlyView.Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner +7 more
wiley +1 more source
Aging and Cancer, EarlyView.ABSTRACT As global populations age, cancer is increasingly becoming a leading cause of morbidity and mortality among older adults, particularly in low‐ and middle‐income countries (LMICs). Despite accounting for the majority of new cancer cases and deaths, older individuals remain underrepresented in cancer research, clinical guidelines, and health ...
Ibrahim Bidemi Abdullateef +2 more
wiley +1 more source
Political Competition in Dual Economies: Clientelism in Latin America [PDF]
Resumen:Este artículo presenta el proyecto de investigación que intenta iluminar los mecanismos que vinculan el clientelismo con la informalidad. En particular la investigación se concentra en las interacciones que tienen lugar durante la competencia ...
M.Rojas, Angela
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Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance
Aging and Cancer, EarlyView.NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang +3 more
wiley +1 more source
Conducción empresarial y flujos de capitales privados hacia América Latina [PDF]
(Disponible en idioma inglés únicamente) Según investigaciones recientes, factores externos y consideraciones de la gestión política son determinantes claves de los flujos de capitales en América Latina.
Alberto Chong +3 more
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