Results 71 to 80 of about 16,478 (220)

Clusters of rare disorders and congenital anomalies in South America. [PDF]

Rev Panam Salud Publica, 2023
Cardoso-Dos-Santos AC, Reales G, Schuler-Faccini L.   +2 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Mercosul: 25 anos de avanços e desafios

Revista Neiba, 2017
O presente artigo busca realizar uma avaliação dos avanços e desafios do MERCOSUL em seus 25 anos. Durante esse período, mudanças ocorreram tanto nos objetivos e na configuração do bloco, como no alinhamento das políticas realizadas pelos governos.
Bernardo Salgado Rodrigues
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Geopolítica dos conflitos socioambientais na América do Sul

Meridiano 47, 2017
O presente artigo objetiva analisar o surgimento de uma onda relevante de conflitos socioambientais na América do Sul tomando como referência a reconstrução dos principais fatos que se desdobraram em distintos países da região.
Eloi Martins Senhoras
doaj  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Genomic surveillance and sequencing of SARS-CoV-2 across South America. [PDF]

Rev Panam Salud Publica, 2023
Ribeiro Dias MF, Andriolo BV, Silvestre DH, Cascabulho PL, Leal da Silva M.   +4 more
europepmc   +1 more source

Establishment of a coculture system for Porphyromonas gingivalis and head and neck squamous cell carcinoma using spheroid culture and LATS inhibition

FEBS Open Bio, EarlyView.
We established a spheroid coculture system enabling viable Porphyromonas gingivalis–HNSCC interactions under normoxic conditions. Inhibition of LATS1/2 maintains tumor cells in an undifferentiated state, which may promote spheroid growth and create a more permissive environment for bacterial persistence.
Yurika Nakajima, Shogo Okazaki, Muneaki Tamura, Shuichi Sato, Kenichi Imai   +4 more
wiley   +1 more source

Spreading further: the first record of the alien bivalve Theora lubrica in the Southwestern Atlantic Ocean

Frontiers in Marine Science
Biological invasions are globally recognized as one of the main drivers of biodiversity loss. Over the past four decades, there has been significant progress in understanding the mechanisms of alien species introduction into marine and estuarine ...
Fabrizio Marcondes Machado, Cristiane Midori Suga, Fabio Kiyoshi Camara Onodera, Mariana Sousa Melo, Thais Viti, Vilma Maria Cavinatto, Ana Carolina da Rocha Lammardo, Carolina Yumi Yonamine, Regina Sawaia Sáfadi, Luis Antonio Nogueira-Junior, Luiz Fernando Maciel Oliva   +10 more
doaj   +1 more source

Cost of lost productivity from acute respiratory infections in South America. [PDF]

Rev Panam Salud Publica, 2023
Mosegui GBG, Antoñanzas F, de Mello Vianna CM.   +2 more
europepmc   +1 more source