Results 111 to 120 of about 3,579,030 (363)

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

open access: yesMolecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad   +17 more
wiley   +1 more source

Conciliar agendas múltiples: la lucha de los sindicatos contra el neoliberalismo en Argentina [PDF]

open access: yes, 2014
En el contexto de la globalización neoliberal, el Área de Libre Comercio de las Américas (ALCA) fue el acuerdo internacio­nal más ambicioso promovido para reducir o eliminar las barreras comerciales internacio­nales en las Américas. Las consecuencias pre­
Rossi, Federico M.
core  

Environmental and Social Change Drive the Explosive Emergence of Zika Virus in the Americas

open access: yesPLoS Neglected Tropical Diseases, 2017
Since Zika virus (ZIKV) was detected in Brazil in 2015, it has spread explosively across the Americas and has been linked to increased incidence of microcephaly and Guillain-Barré syndrome (GBS).
Sofia Ali   +18 more
semanticscholar   +1 more source

Tumor and germline testing with next generation sequencing in epithelial ovarian cancer: a prospective paired comparison using an 18‐gene panel

open access: yesMolecular Oncology, EarlyView.
Genetic testing in epithelial ovarian cancer includes both germline and tumor‐testing. This approach often duplicates resources. The current prospective study assessed the feasibility of tumor‐first multigene testing by comparing tumor tissue with germline testing of peripheral blood using an 18‐gene NGS panel in 106 patients.
Elisabeth Spenard   +12 more
wiley   +1 more source

Afrodescendants, Law, and Race in Latin America [PDF]

open access: yes, 2019
Law and Society research in and about Latin America has been particularly beneficial in elucidating the gap between the ideals of racial equality laws in the region and the actual subordinated status of its racialized subjects.
Hernandez, Tanya K.
core   +2 more sources

Invasion of sorghum in the Americas by a new sugarcane aphid (Melanaphis sacchari) superclone

open access: yesPLoS ONE, 2018
In the United States (US), the sugarcane aphid (SCA) Melanaphis sacchari (Zehnter) (Hemiptera: Aphididae) was introduced in the 1970s, however at that time it was only considered a pest of sugarcane. In 2013, a massive outbreak of M.
Samuel Nibouche   +9 more
semanticscholar   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

open access: yesMolecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang   +8 more
wiley   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

open access: yesMolecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece   +18 more
wiley   +1 more source

Las Américas y el Mundo 2008 [PDF]

open access: yes, 2009
El objetivo central de este estudio es llenar un vacío de información empírica en un área estratégica para la región, donde los datos independientes y confiables son escasos.

core  

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