Results 101 to 110 of about 19,299 (229)

Amyloid β alters vascular CaV1.2 channel spatiotemporal properties

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Amyloid‐β1‐42 (Aβ1‐42) triggers a male‐specific signalling cascade influencing CaV1.2 spatiotemporal properties in cerebral vascular smooth muscle. The signalling pathway involves NADPH oxidase (NOX)‐derived reactive oxygen species (ROS) activation of protein kinase C (PKC). Aβ1‐42 can also activate protein kinase A (PKA).
Jade L. Taylor   +5 more
wiley   +1 more source

BiGraph‐DTA: Predicting drug–target interactions of hepatoprotective agents with graph convolutional networks

open access: yesQuantitative Biology, Volume 14, Issue 1, March 2026.
Abstract Predicting drug–target affinity (DTA) is critical for discovering and developing hepatoprotective agents that can prevent and treat liver diseases. In this study, we propose BiGraph‐DTA, a new predictive model for identifying DTA score prediction for hepatoprotective compounds by combining graph convolutional networks and bidirectional long ...
Arief Sartono   +4 more
wiley   +1 more source

The regional evolution of a dryland fluvio‐aeolian and lacustrine succession in response to allocyclic forcing: insights from the Early Permian Cutler Group, Utah, USA

open access: yesSedimentology, Volume 73, Issue 2, Page 297-354, February 2026.
ABSTRACT Preserved allocyclic signatures in the rock record often reflect basin‐scale climatic variability and serve as key proxies for correlating ancient dryland successions. The notion of climate cyclicity, however, remains largely untested on regionally constrained, outcrop‐calibrated studies.
Oliver Button   +4 more
wiley   +1 more source

Summary of space imagery studies in Utah and Nevada [PDF]

open access: yes
The author has identified the following significant results. An enhanced enlargement of a S190B color image at a scale of 1/19,200 of the Bingham porphyry copper deposit has compared a geological map of the area with the space imagery map as fair for the
Jensen, M. L.
core   +1 more source

Facies analysis provides new insights into event bed deposition in a hadal trench environment

open access: yesSedimentology, Volume 73, Issue 2, Page 441-477, February 2026.
ABSTRACT Hadal trenches preserve exceptional sedimentary archives of past geological events, yet their depositional processes remain poorly constrained. The Japan Trench captures complex earthquake‐triggered event beds that record repeated sediment‐gravity flows that deliver terrigenous and biogenic material into the trench, informing palaeoseismic ...
Mishelle Muthre   +6 more
wiley   +1 more source

A step further in our commitment to support early career researchers (ECRs)

open access: yesFEBS Open Bio, Volume 16, Issue 1, Page 4-10, January 2026.
As a not‐for‐profit open access journal, FEBS Open Bio is proud to support the scientific community not only through the publication of open access articles available to all but also through the charitable activities of FEBS. In this editorial, we look back at some of the highlights of the past year and look forward to the new initiatives planned for ...
Sara Fuentes, Miguel A. De la Rosa
wiley   +1 more source

Reconfigurable Nucleic Acid Nanoparticles with Therapeutic RNAi Responses to Intracellular Disease Markers

open access: yesAdvanced Functional Materials, Volume 36, Issue 5, 15 January 2026.
Many known diseases arise from dysregulated gene expression, and differentially expressed genes can serve as biomarkers to distinguish diseased cells from healthy tissues. In this study, reconfigurable nucleic acid nanoparticles (recNANPs) are introduced that can detect overexpressed cancer biomarkers and subsequently release RNAi inducers to silence ...
Yelixza I. Avila   +7 more
wiley   +1 more source

Integrated Metallo‐Dielectric 3D Hotspots From High Refractive Index Nanodiamond‐Plasmonic Gold Cryosoret Nano‐Assemblies for Photonic Crystal Enhanced Fluorescence

open access: yesAdvanced Functional Materials, Volume 36, Issue 5, 15 January 2026.
This work presents a novel sensing platform using metallo‐dielectric cryosoret nano‐assemblies and lossless photonic crystals to overcome limitations of conventional plasmonic biosensors. The hybrid system enhances both electric and magnetic field interactions, enabling amplified fluorescence, ultralow detection limits, and prism‐free, objective‐free ...
Seemesh Bhaskar   +5 more
wiley   +1 more source

Multifunctional Bamboo Based Materials Empowered by Multiscale Hierarchical Structures—A Critical Review

open access: yesAdvanced Materials, Volume 38, Issue 2, 8 January 2026.
This review summarizes the latest progress in transforming renewable bamboo resources into high‐value functional materials. It emphasizes how to leverage bamboo's multiscale hierarchical structures to realize innovative applications in energy, construction, environment, and medicine, providing key insights for developing high‐performance bio‐based ...
Yuxiang Huang   +13 more
wiley   +1 more source

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