Results 81 to 90 of about 173,577 (262)

Humans and Gold Mining in Peru: A Place-Based Synthesis of Historical Legacies, Environmental Challenges, and Pathways to Sustainability

Humans
Gold mining has played a central role in shaping Peruvian society from pre-Inca civilizations to the present. However, existing literature offers fragmented perspectives, often focusing on isolated themes such as metallurgy, colonial mercury use, or ...
Julia Zea, Pablo A. Garcia-Chevesich, Carlos Zevallos, Madeleine Guillen, Francisco Alejo, Eliseo Zeballos, Johan Vanneste, Henry Polanco, John E. McCray, Christopher Bellona, David C. Vuono   +10 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Amalgamating Provincial Health Authorities: Assessing the Experience of Nova Scotia

Health Reform Observer - Observatoire des Réformes de Santé, 2019
Reflecting the shift away from regionalized health governance in Canada's provinces, the Nova Scotia government consolidated its nine Distinct Health Authorities into the single Nova Scotia Health Authority as of 1 April 2015.
Katherine Fierlbeck
doaj   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Trabajadores y técnicas mineras andinas en las fiebres del oro del mundo en el siglo XIX

Nuevo mundo - Mundos Nuevos, 2015
During the XIX century, the alluvial gold findings in the United Sates, Australia, New Zealand and other territories, attracted numerous adventurers, including South American immigrants with knowledge in mining tasks.
Inés Herrera Canales
doaj   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

MODEL KERUKUNAN SOSIAL PADA MASYARAKAT MULTIKULTURAL CINA BENTENG (KAJIAN HISTORIS DAN SOSIOLOGIS)

Sosio Didaktika: Social Science Education Journal, 2014
This study was conducted to gain an overview of the historical and sociological perspective of the model of social harmony in a multicultural society of Cina Benteng, Tangerang.
Muhamad Arif
doaj   +1 more source

Fields and Fusions: Hrushovski constructions and their definable groups

, 2010
An overview is given of the various expansions of fields and fusions of strongly minimal sets obtained by means of Hrushovski's amalgamation method, as well as a characterization of the groups definable in these ...
Wagner, Frank Olaf
core   +1 more source