Results 81 to 90 of about 78,289 (273)
Regulation of Iran's Upstream Oil and Gas Industries in Light of Islamic Jurisprudence and Law [PDF]
پژوهشنامه حقوق اسلامی ∴ Introduction ∴ The upstream oil and gas industry in Iran is a cornerstone of the nation's economy but is currently experiencing significant market failures and inefficiencies. These challenges stem from various factors, including economies of scale,
Mohammad Hosein Esfandiarpour +1 more
doaj +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Computational and Structural Biotechnology JournalProtein secondary structure prediction (PSSP) is a pivotal research endeavour that plays a crucial role in the comprehensive elucidation of protein functions and properties.
Benzhi Dong +6 more
doaj +1 more source
Molecular Oncology, EarlyView.CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak +10 more
wiley +1 more source
International Conference on Structural Reform and the Transformation of rganisations and Business Homerton College, University of Cambridge, U.K [PDF]
The government of Ontario has made a number of major changes in the way that municipalities are governed and financed. Some municipalities have been forced to amalgamate despite opposition from their residents.
HARVEY SCHWARTZ
core
Molecular Oncology, EarlyView.Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor +2 more
wiley +1 more source
Chaos Theory and Applications, 2023 Chaos, comprehended characteristically, is the mathematical property of a dynamical system which is a deterministic mathematical model in which time can be either continuous or discrete as a variable.
Dumitru Baleanu, Yeliz Karaca
doaj
, 2012 Let C_1 and C_2 be strong amalgamation classes of finite structures, with disjoint finite signatures sigma and tau. Then C_1 wedge C_2 denotes the class of all finite (sigma cup tau)-structures whose sigma-reduct is from C_1 and whose tau-reduct is from ...
Bodirsky, Manuel
core +1 more source
Molecular cancer prevention: Intercepting disease
Molecular Oncology, EarlyView.Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco +2 more
wiley +1 more source