Results 121 to 130 of about 486 (156)
Some of the next articles are maybe not open access.
Total Synthesis of α‐ and β‐Amanitin
Angewandte Chemie International Edition, 2020Abstractα‐Amanitin and related amatoxins have been studied for more than six decades mostly by isolation from death cap mushrooms. The total synthesis, however, remained challenging due to unique structural features. α‐Amanitin is a potent inhibitor of RNA polymerase II. Interrupting the basic transcription processes of eukaryotes leads to apoptosis of
Christian Lutz +4 more
openaire +2 more sources
1975
So far, most experimental investigations concerning amanitin poisoning have been done in the mouse or in the rat. In order to obtain conditions which could be better compared to human intoxication, we chose the dog for experiments. Among the amatoxins available, there are two compounds, which can be radioactively labelled: 14[C]O-methyl-γ-amanitin and ...
Faulstich, H., Fauser, U.
openaire +2 more sources
So far, most experimental investigations concerning amanitin poisoning have been done in the mouse or in the rat. In order to obtain conditions which could be better compared to human intoxication, we chose the dog for experiments. Among the amatoxins available, there are two compounds, which can be radioactively labelled: 14[C]O-methyl-γ-amanitin and ...
Faulstich, H., Fauser, U.
openaire +2 more sources
Analytical Biochemistry, 1985
A high-performance liquid chromatographic assay of alpha-amanitin and beta-amanitin in human serum, urine, or stomach washings is described. Sample preparation involves a chemical step with deproteinization and organic solvent treatment, and a selective cleanup and concentration step on reversed-phase prepacked cartridges.
F, Jehl +5 more
openaire +2 more sources
A high-performance liquid chromatographic assay of alpha-amanitin and beta-amanitin in human serum, urine, or stomach washings is described. Sample preparation involves a chemical step with deproteinization and organic solvent treatment, and a selective cleanup and concentration step on reversed-phase prepacked cartridges.
F, Jehl +5 more
openaire +2 more sources
Antidotes to Experimental cc-Amanitin Poisoning
Nature New Biology, 1972THE two most important toxic cyclopeptides isolated from the mushroom Amanita phalloides (death cap) are phalloidin and α-amanitin1, 2. The latter is considered to be responsible for the fatal cases of poisoning. Up to now, protection has been demonstrated either with a non-toxic chemical analogue (antamanide) isolated from the toadstool itself and ...
openaire +2 more sources
Comment on: amanitin intoxication
Clinical Toxicology, 2023Cellier, Morgane +6 more
openaire +3 more sources
Comment on: Amanitin intoxication
Clinical Toxicology, 2022Brent A. Neuschwander-Tetri +1 more
openaire +2 more sources
New Aspects of Amanitin and Phalloidin Poisoning
1996The green death cap Amanita phalloides produces two families of toxic peptides, the amatoxins and the phallotoxins. Amatoxins are by far the more dangerous toxins and account for all fatalities occurring in human mushroom poisoning.
H, Faulstich, T, Wieland
openaire +2 more sources
Production of high purity beta amanitin
2012Amaç: Beta amanitin nadiren bilimsel araştırmalarda kullanılmakta ve kullanımı gün geçtikçeartmaktadır. Piyasada bu ürün %90 saflıkta ticari olarak satılmaktadır. Bu araştırmada yükseksaflıkta beta amanitin üretme yöntemi tanımlanmıştır.Yöntem: Saflaştırma işlemi Amanita phalloides mantarlarından ekstraksiyonla yapılmıştır.Öncelikle bu mantarlar ...
YAYKAŞLI, Kürşat Oğuz +5 more
openaire +3 more sources