Results 41 to 50 of about 25,332 (224)
Acta Ophthalmologica, EarlyView.Abstract Purpose To assess in Royal College of Surgeons (RCS) rats if the combination of two previously documented neuroprotective strategies: minocycline administration and bone marrow–derived mononuclear cells (BM‐MNCs) intravitreal transplantation, offers enhanced neuroprotection compared with each treatment alone.
Alba Videla‐Ristol +6 more
wiley +1 more source
Novel gene variants in Polish patients with Leber congenital amaurosis (LCA)
Orphanet Journal of Rare Diseases, 2020 Background Leber congenital amaurosis (LCA) is a rare retinal disease that is the most frequent cause of congenital blindness in children and the most severe form of inherited retinal dystrophies.
Anna Skorczyk-Werner +3 more
doaj +1 more source
Exploring fundus‐controlled mesopic and scotopic perimetry in inherited retinal disease
Acta Ophthalmologica, EarlyView.Abstract Purpose Microperimetry is increasingly used as an outcome measure in clinical trials for retinal disease. This study compares mesopic and scotopic microperimetry in a heterogeneous cohort of patients with inherited retinal disease to assess their suitability as clinical trial outcome measures and to determine the most appropriate testing ...
Laura J. Taylor +4 more
wiley +1 more source
Genetic testing for Leber congenital amaurosis
The EuroBiotech Journal, 2017 We studied the scientific literature and disease guidelines in order to summarize the clinical utility of genetic testing for Leber congenital amaurosis (LCA).
Abeshi Andi +5 more
doaj +1 more source
Cell Proliferation, EarlyView.Neurological disorders are hard to treat. Stem cell‐derived neural organoids enable research, and their transplantation aids CNS therapy, with this article reviewing relevant advances, challenges and prospects. ABSTRACT Neurological disorders are often devastating and notoriously difficult to repair, creating an urgent need for novel research models ...
Yutong Wang +8 more
wiley +1 more source
Revista de la Facultad de Medicina, 1939 Se estudia para definir y se define para aplicar: tal el criterio que debe gobernar la mente de quienes se procuran el saber con finalidades prácticas y tal el pensamiento que he guiado mi ceguera, la cual, no ha sido para mí dolorosa y trágica invasión ...
Juan Antonio Pardo Ospina
doaj
Development of an optimized AAV2/5 gene therapy vector for Leber congenital amaurosis owing to defects in RPE65 [PDF]
, 2016 Leber congenital amaurosis is a group of inherited retinal dystrophies that cause severe sight impairment in childhood; RPE65-deficiency causes impaired rod photoreceptor function from birth and progressive impairment of cone photoreceptor function ...
Abelleira-Hervas, L +12 more
core +1 more source
Techniques for subretinal injections in animals
Veterinary Ophthalmology, Volume 28, Issue 2, Page 506-518, March 2025.Abstract Subretinal injections are not commonly performed during clinical treatment of animals but are frequently used in laboratory animal models to assess therapeutic efficacy and safety of gene and cell therapy products. Veterinary ophthalmologists are often employed to perform the injections in the laboratory animal setting, due to knowledge of ...
Ryan F. Boyd, Simon M. Petersen‐Jones
wiley +1 more source
Headaches with ocular localization and involvement Cefaleas de localización y compromiso oculares
Iatreia, 2005 The most frequent primary headaches, including migraine variants, and intrinsic optic nerve disorders that produce headache, are reviewed. The latter are often accompanied by autonomic nervous system alterations which lead to vasomotor changes ...
Marta Lucía Muñoz Cardona +3 more
doaj
Clinical Case ReportsKey Clinical Message The discovery of compound heterozygous NMNAT1 mutations (c.245T>C; p.Val82Ala and c.575A>G; p.Asp192Gly) provides a genetic explanation for Leber congenital amaurosis 9 in an Iranian patient.
Mostafa Neissi +6 more
doaj +1 more source