Results 101 to 110 of about 381,771 (314)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

open access: yesFEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid   +3 more
wiley   +1 more source

How Parents Influence Deviant Behavior among Adolescents: An Analysis of their Family Life, Community, and Peers [PDF]

open access: yes, 2012
The goal of this literature review is to analyze the effect the family has on an adolescent’s behavior. It is believed that parents have direct and indirect control.
Carlson, Amber
core   +1 more source

Pudendal nerve stimulation for treatment of lower urinary tract symptoms: A systematic review of safety, technical feasibility and clinical efficacy

open access: yesContinence
Aim:: Pudendal nerve stimulation (PNS) is a promising neuromodulation option. While sacral neuromodulation (SNM) and posterior tibial nerve stimulation (PTNS) are established third-line treatments for lower urinary tract dysfunction (LUTS), the pudendal ...
Siemen Herroelen   +5 more
doaj   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

open access: yesFEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point   +7 more
wiley   +1 more source

Discolomopsis dominicana : a new genus and species of Endomychidae (Coleoptera) from Dominican amber [PDF]

open access: yes, 2006
Discolomopsis, a new genus of Endomychidae (Coleoptera: Cucujoidea), is described and illustrated based on a fossil endomychid embedded in amber resin from the Dominican Republic. Discolomopsis dominicana sp. nov.
Shockley, Floyd W.
core  

Quantum-accurate machine learning potentials for metal-organic frameworks using temperature driven active learning

open access: yesnpj Computational Materials
Understanding structural flexibility of metal-organic frameworks (MOFs) via molecular dynamics simulations is crucial to design better MOFs. Density functional theory (DFT) and quantum-chemistry methods provide highly accurate molecular dynamics, but the
Abhishek Sharma, Stefano Sanvito
doaj   +1 more source

Alcohol‐induced altered glycans in human tracheal epithelial cells promote bacterial adhesion

open access: yesFEBS Open Bio, EarlyView.
Alcohol induces altered glycans to promote bacteria adhesion. Heavy alcohol drinking is known to increase the risk of bacterial pneumonia. However, the link between alcohol levels and risk of infection remains underexplored. Recently, we found that alcohol induced α2‐6sialo mucin O‐glycans in human tracheobronchial epithelial cells, which mediated the ...
Pi‐Wan Cheng   +2 more
wiley   +1 more source

An Analysis of Differences in Approaches to Systems of Linear Equations Problems Given Multiple Choice Answers [PDF]

open access: yes, 2012
This descriptive study focuses on the approaches college students (ages 20 -24) use when solving systems of linear equations problems that have multiple choice answers. Participants were from a midsize public university in the northeast.
Lagasse, Amber
core   +1 more source

Chemical and palaeoentomological evidence of a relationship between early Eocene Belgian and Oise (France) ambers

open access: yesScientific Reports
Of the early Eocene amber deposits known across the world, Belgian amber has been mostly absent from the relevant literature. We reinvestigated amber held in the palaeobotanical collection of the Royal Belgian Institute of Natural Sciences, Brussels ...
Leyla J. Seyfullah   +3 more
doaj   +1 more source

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