Results 191 to 200 of about 1,228,351 (351)

A Dynamic Gate Enables Regioselective Hydroxylation of Free Arginine by a Non‐Canonical Heme Enzyme

open access: yesAdvanced Science, EarlyView.
The YqcI/YcgG enzyme AglA employs a unique “sandwich” fold and a dynamic gating mechanism to selectively hydroxylate AMPn‐Arg at Nε. Site‐directed mutations reprogram regioselectivity or enable activity on free arginine by altering hydrogen‐bond networks, precisely positioning substrates.
Yuan Sun   +12 more
wiley   +1 more source

A Quantum Framework for Protein Binding‐Site Structure Prediction on Utility‐Level Quantum Processors

open access: yesAdvanced Science, EarlyView.
This study presents a hybrid quantum‐classical framework for accurate prediction of protein structures on utility‐level quantum processors. We evaluate the practical application of the Variational Quantum Eigen‐solver (VQE) in protein structure prediction and demonstrate its superiority over state‐of‐the‐art deep learning methods in molecular docking ...
Yuqi Zhang   +10 more
wiley   +1 more source

When a model gives you mixed signals: cognitive effects and visual behavior. [PDF]

open access: yesProcess Sci
Abbad-Andaloussi A   +4 more
europepmc   +1 more source

IGF‐1 Deficiency Serves as an Integrated Biomarker Pathogenic Driver and Predictor in Poor Ovarian Response

open access: yesAdvanced Science, EarlyView.
IGF‐1 deficiency underlies poor ovarian response (POR), as reduced levels in follicular fluid and granulosa cells impair antral follicle formation and compromise reproductive outcomes. Including IGF‐1 as a biomarker significantly enhances the accuracy of models predicting both PORrisk and pregnancy success.
Zhu Hu   +9 more
wiley   +1 more source

Freely foraging macaques value information in ambiguous terrains. [PDF]

open access: yesSci Rep
Shahidi N   +4 more
europepmc   +1 more source

Determination of the Exchange Current Density at Lithium │ Polymer Electrolyte Interfaces

open access: yesAdvanced Science, EarlyView.
This work presents a comprehensively validated method to determine the exchange current density (j0) at the interface of lithium metal and polymer electrolytes by combining electrochemical impedance spectroscopy with Bayesian inference and distribution of relaxation times analyses to successfully deconvolute solid electrolyte interphase and charge ...
Katrin Geng   +4 more
wiley   +1 more source

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