Results 41 to 50 of about 1,432,903 (295)

Verloren normaliteit? Van het verlangen naar autoriteit naar een Beauvoiraanse ethiek der dubbelzinnigheid

open access: yesKrisis, 2022
The authority of a souverain no longer seems important if one wants to analyse complex modern democratic societies. At the same time, one can observe an increasing desire for authority in social and political life, a longing for orientation and guidance.
Maren Wehrle
doaj   +1 more source

Comments on Gauge Equivalence in Noncommutative Geometry [PDF]

open access: yes, 1999
We investigate the transformation from ordinary gauge field to noncommutative one which was introduced by N.Seiberg and E.Witten (hep-th/9908142). It is shown that the general transformation which is determined only by gauge equivalence has a path ...
Asakawa, Tsuguhiko, Kishimoto, Isao
core   +2 more sources

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

PICALM::MLLT10 translocated leukemia

open access: yesFEBS Letters, EarlyView.
This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen   +7 more
wiley   +1 more source

Semantic Ambiguity and Perceived Ambiguity [PDF]

open access: yes, 1994
I explore some of the issues that arise when trying to establish a connection between the underspecification hypothesis pursued in the NLP literature and work on ambiguity in semantics and in the psychological literature.
Poesio, Massimo
core   +1 more source

Integrated genomic and proteomic profiling reveals insights into chemoradiation resistance in cervical cancer

open access: yesMolecular Oncology, EarlyView.
A comprehensive genomic and proteomic analysis of cervical cancer revealed STK11 and STX3 as a potential biomarkers of chemoradiation resistance. Our study demonstrated EGFR as a therapeutic target, paving the way for precision strategies to overcome treatment failure and the DNA repair pathway as a critical mechanism of resistance.
Janani Sambath   +13 more
wiley   +1 more source

Context, Content, and the Occasional Costs of Implicature Computation

open access: yesFrontiers in Psychology, 2019
The computation of scalar implicatures is sometimes costly relative to basic meanings. Among the costly computations are those that involve strengthening “some” to “not all” and strengthening inclusive disjunction to exclusive disjunction.
Raj Singh
doaj   +1 more source

»So fängt nur Chopin an, ... so schließt nur er«. Initial- und Finalgestaltung in Chopins Mazurken [PDF]

open access: yesZeitschrift der Gesellschaft für Musiktheorie, 2010
Bereits Robert Schumann betonte Frédéric Chopins Hang zur individuellen Gestaltung von Anfängen und Enden. Im Sinne der Innovationsästhetik des 19. Jahrhunderts suchte Chopin in allen Gattungen nach immer neuen Möglichkeiten, Musik beginnen und enden zu ...
Michael Lehner
doaj   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Testosterone and Cortisol Jointly Predict the Ambiguity Premium in an Ellsberg-Urns Experiment

open access: yesFrontiers in Behavioral Neuroscience, 2017
Previous literature has tried to establish whether and how steroid hormones are related to economic risk-taking. In this study, we investigate the relationship between testosterone (T) and cortisol (C) on one side and attitudes toward risk and ambiguity ...
Giuseppe Danese   +3 more
doaj   +1 more source

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