The social construction of Aduhelm in the context of pharmaceutical ambiguity: exploring narratives from informal caregivers, medical professionals, and redditors on r/Alzheimers. [PDF]
Front SociolSimoni Z, Hilfiker V.
europepmc +1 more source
Advanced Science, EarlyView.A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin +6 more
wiley +1 more source
A Positive Semidefinite Safe Approximation of Multivariate Distributionally Robust Constraints Determined by Simple Functions. [PDF]
J Optim Theory ApplDienstbier J, Liers F, Rolfes J.
europepmc +1 more source
Time‐Efficient and Informatic‐Skill‐Light Gap‐Filling for Telomere‐to‐Telomere Genome Assembly
Advanced Science, EarlyView.The paper introduces a novel auxiliary software toolbox GapSuite, consisting of two tools Gap‐Aid and Gap‐Graph, which guides users to fill gaps in chromosome‐level genome assembly using sequence‐extension‐based and assembly‐graph‐based strategies. The two tools enable users with limited informatics expertise to efficiently complete gap‐filling on ...
Dong Xu +8 more
wiley +1 more source
Postoperative Urinary Retention: A Call for Objective Assessment and Standardized Postoperative Protocols. [PDF]
CureusEggemann C, Nobrega L.
europepmc +1 more source
Biomechanics‐Driven 3D Architecture Inference from Histology Using CellSqueeze3D
Advanced Science, EarlyView.CellSqueeze3D reconstructs 3D cellular architecture from standard 2D histology images using biomechanical constraints and optimization. Validated on clinical datasets, it enables accurate tissue phenotyping, predicts gene mutations, and reveals significant correlations between nuclear‐cytoplasmic ratio entropy and tumor progression.
Yan Kong, Hui Lu
wiley +1 more source
Evaluation of GPS/BDS-3 PPP-AR Using the FCBs Predicted by GA-BPNN Method with iGMAS Products. [PDF]
Sensors (Basel)Wang J, Yang G, Liu Q, Xu Y.
europepmc +1 more source
Unraveling the Origin of Exceptional Activity in NiMo Alloys for Alkaline Hydrogen Evolution
Advanced Science, EarlyView.This study resolves the controversy regarding the active origin of Nickel‐molybdenum (NiMo) alloys for alkaline hydrogen evolution. By combining surface Pourbaix diagrams with microkinetic modeling, we demonstrate that the O‐covered Ni3Mo surface drives activity through a synergistic mechanism: Mo sites facilitate water dissociation while adjacent Ni ...
Yuefeng Zhang +4 more
wiley +1 more source
Ligand‐Induced Electronic Response Enables Predictive QM/MM Simulations
Advanced Science, EarlyView.Quantum mechanics/molecular mechanics (QM/MM) simulations are powerful tools for modeling complex molecular systems; however, their predictability has been constrained by the ambiguous definition of the QM region. An electronically informed protocol is introduced that defines QM regions by quantifying guest‐induced orbital shifts and charge ...
Nichika Ozawa +2 more
wiley +1 more source
Quantum Statistical Mechanics of Electronically Open Molecules: Reduced Density Operators. [PDF]
J Chem Theory ComputPedersen J, Sannes BS, Høyvik IM.
europepmc +1 more source