Results 151 to 160 of about 76,797 (310)

Gut Mycobiota‐Associated Tryptophan Catabolites Protect Against Metabolic Dysfunction‐Associated Steatotic Liver Disease

Advanced Science, EarlyView.
ABSTRACT Accumulating evidence suggests that the intestinal microbiota participates in the progression of metabolic dysfunction‐associated steatotic liver disease (MASLD) through microbiota‐host interaction. However, the beneficial role of commensal mycobiota in MASLD progression remains poorly understood.
Shuping Qiao, Shuangya Fan, Juan Xu, Zhen Xu, Chen Peng, Junxing Qu, Ziqian Bing, Shizhen Zhou, Sunan Shen, Guifang Xu, Yue Zhao, Tingting Wang   +11 more
wiley   +1 more source

Genome‐Wide CRISPR Screen Identifies a microRNA Orchestrating Pleiotropic Resistance to Targeted Therapy and T Cell Immunity in Melanoma

Advanced Science, EarlyView.
A genome‐wide microRNA CRISPR screen identifies miR‐18a as a master regulator of cross‐resistance in melanoma. Loss of miR‐18a activates the AJUBA–YAP/Hippo axis to confer BRAFi resistance and enhances THBS1–CD47 interaction to impair CD8+ T cell immunity. hnRNP A1 is identified as an upstream regulator of miR‐18a processing.
Zhao Wang, Haotian Liu, Xueqi Wang, Jianjin Teng, Zihan Zheng, Jingya Zhang, Wanyi Xiao, Qian Liang, Jiaxin Li, Xiaomeng Jia, Xin Feng, Hongzhang Cui, Menghan Luo, Tielong Yang, Liuxing Wu, Ke Zhao, Weilong Yang, Mulin Jun Li, Dandan Huang, Jilong Yang   +19 more
wiley   +1 more source

Machine Learning for Green Solvents: Assessment, Selection and Substitution

Advanced Science, EarlyView.
Environmental regulations have intensified demand for green solvents, but discovery is limited by Solvent Selection Guides (SSGs) that quantify solvent sustainability. Training a machine learning model on GlaxoSmithKline SSG, a database of sustainability metrics for 10,189 solvents, GreenSolventDB is developed. Integrated with Hansen solubility metrics,
Rohan Datta, Janhavi Nistane, Abhishek Sose, Harikrishna Sahu, Rampi Ramprasad   +4 more
wiley   +1 more source

Disorder‐Induced Extremely Low Thermal Conductivity of Graphite Fluoride

Advanced Science, EarlyView.
This article investigates the effect of fluorination on the thermal conductivity of graphite fluoride, demonstrating the relationship between structural modification and thermal conductivity in an extreme case. The record‐low through‐plane thermal conductivity measured in exfoliated graphite fluoride flakes was found to correlate with the wide ...
Wonsik Lee, Donghoon Moon, Ziyan Qian, Jinwoo Kim, Changheon Kim, Yeojin Lee, Hyobin Yoo, Richard B. Wilson, Qiye Zheng, Gwan‐Hyoung Lee, Hyejin Jang   +10 more
wiley   +1 more source

Characterization of Time-Consistent Sets of Measures in Finite Trees [PDF]

In this paper we give an alternative characterization for time-consistent sets of measures in a discrete setting. For each measure p in a time-consistent set P we get a distinct set of predictable processes which in return describe the p uniquely.
Monika Bier
core  

Perceived IT Ambiguity: Development of a Measurement Instrument

, 2018
Information technologies (IT) have reached such degrees of functional richness that forming a complete, coherent, and stable understanding of a given IT product may be challenging for some users. The need to theorize this phenomena and to measure its effect on IT adoption empirically is rife.
Pillet, Jean-Charles, Carillo, Kevin, Pigni, Federico, Vitari, Claudio   +3 more
openaire   +2 more sources

Prior Expectations Bias Confidence Judgments Through Parietal Alpha‐Band Modulation

Advanced Science, EarlyView.
ABSTRACT Humans possess the metacognitive ability to estimate the likely accuracy of their own decisions through confidence judgments. Yet, whether prior information shapes confidence and the neural mechanisms mediating such influence, remain to be determined.
Luca Tarasi, Anna Pasini, Domenico Romanazzi, Margherita Covelli, Vincenzo Romei   +4 more
wiley   +1 more source

Essays on the Foster-Hart measure of riskiness and ambiguity in real options games

, 2016
Hellmann T. Essays on the Foster-Hart measure of riskiness and ambiguity in real options games.
Hellmann, Tobias
core  

Capital Asset Pricing under Ambiguity

, 2020
This paper generalizes the standard mean-variance paradigm to a mean-varianceambiguity paradigm by relaxing the assumption that probabilities are known and instead assuming that probabilities are themselves random.
Eitan Goldman, Itzhak Gilboa, Ilan Cooper, Mark Machina, Yakov Amihud, Simon Benninga, Avi Wohl, Menachem Abudy, † I Thank, Ilan Kremer, Paul Wachtel, Adam Brandenburger, Menachem Brenner, Edi Karni, Michael Stutzer, Xavier Gabaix, William Greene, Pierpaolo Battigalli, Yehuda Izhakian, Ruth Kaufman, Thomas Sargent, Yaniv Grinstein, Sujoy Mukerji, Yacov Oded, Azi Ben-Rephael, Laura Veldkamp, David Schmeidler, Jaime Zender, Doron Abramov, Itamar Drechsler   +29 more
core  

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source