Results 151 to 160 of about 410,199 (291)

A Modular DNAzyme for Precise Visualization and Intervention of Alternative Splicing Isoforms in Live Cells

open access: yesAdvanced Science, EarlyView.
A Stringent dUPlex‐activated Error Robust (SUPER) DNAzyme system enables real‐time imaging of alternative mRNA splicing (e.g., Bcl‐xL/Bcl‐xS) in living cells via target‐triggered split‐DNAzyme reassembly and dual‐color fluorescence. It also achieves mRNA‐selective knockdown through DNAzyme‐based gene regulation, serving as a versatile tool for splicing
Mengru Lin   +6 more
wiley   +1 more source

vEMRec: High‐Resolution Volume Electron Microscopy Reconstruction Based on Structure‐Preserving and High‐Fidelity 3D Alignment

open access: yesAdvanced Science, EarlyView.
vEMRec is a frequency‐adaptive computational framework for three‐dimensional alignment in volume electron microscopy. It integrates feature‐based rigid alignment with Gaussian filter‐guided elastic registration to correct rigid misalignments and nonlinear distortions while preserving structural fidelity.
Zhenbang Zhang   +7 more
wiley   +1 more source

cuteHap: Haplotype‐Aware Structural Variant Detection in Phased Long‐Read Sequencing Data

open access: yesAdvanced Science, EarlyView.
cuteHap is a haplotype‐aware structural variant detection method designed for phased long‐read sequencing. By employing self‐adaptive clustering and credibility‐prioritized beam search algorithms, cuteHap generates accurate haplotype‐resolved calls and outperforms state‐of‐the‐art tools.
Shuqi Cao   +7 more
wiley   +1 more source

Analysis of BDS Fractional Cycle Biases and PPP Ambiguity Resolution. [PDF]

open access: yesSensors (Basel), 2019
Jiang W   +5 more
europepmc   +1 more source

Noise Fingerprints as a Quantitative Order Parameter for Polarization‐ and Defect‐Mediated Switching in Hafnia Ferroelectrics

open access: yesAdvanced Science, EarlyView.
Low‐frequency noise fingerprints in hafnia ferroelectrics provide a quantitative handle to resolve the long‐standing debate between polarization‐mediated and defect‐mediated switching. By tuning oxygen vacancy density via ALD O3 dose time and applying a physically constrained deconvolution, we extract bias‐resolved current fractions for both mechanisms
Ryun‐Han Koo   +8 more
wiley   +1 more source

Nanozymes for Energy and Environmental Sustainability

open access: yesAdvanced Science, EarlyView.
At present, the widely used nanozymes are oxidoreductase and hydrolase, which have proved to have great application prospects in energy and environment. ABSTRACT Nanozymes have shown remarkable promise in addressing pressing challenges in energy and environmental sustainability.
Xiaoqi Li, Jinxing Chen, Shaojun Dong
wiley   +1 more source

Synergistic Enhancement of Catalytic Activities in Ligand‐Regulated Carbon Dots‐Ferric Ion Nanozymes via UV‐Enhanced Peroxidase‐Oxidase

open access: yesAdvanced Science, EarlyView.
Three CDs‐Fe nanozymes functionalized with tailor‐made ligands (TPP, HEDP, and DTPA) are synthesized via hydrothermal carbonization and coordination chemistry. A ligand‐regulation strategy for CDs‐Fe nanozymes achieves tunable enzyme‐mimicking activities and a powerful synergistic effect between POD and UV‐induced OXD pathways, paving the way for ...
Xiangli Li   +4 more
wiley   +1 more source

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