Results 121 to 130 of about 658,933 (385)

Effects of Sodium‐Glucose Cotransporter 2 Inhibitors on 24‐Hour Ambulatory Blood Pressure: A Systematic Review and Meta‐Analysis

Journal of the American Heart Association : Cardiovascular and Cerebrovascular Disease, 2017
Background Sodium‐glucose cotransporter 2 (SGLT2) inhibitors are a novel class of antihyperglycemic agents that improve glycemic control by increasing glycosuria.
W. Baker, L. Buckley, Michael S. Kelly, John D. Bucheit, Eric D. Parod, Roy Brown, S. Carbone, A. Abbate, Dave L Dixon   +8 more
semanticscholar   +1 more source

Zoborg: On‐Demand Climbing Control for Cyborg Beetles

Advanced Science, EarlyView.
A novel on‐demand climbing protocol enables Zoborg (a cyborg beetle from the living Zophobas morio) to seamlessly transition from horizontal floors to vertical walls. Multiple unrestrained mechanosensors allow wall sensing while electrical stimulation of the elytron initiates climbing. Leveraging the agile locomotion and exceptional adaptability of the
Lachlan Fitzgerald, H. Nhan Le, Robbie S. Wilson, H. Duoc Nguyen, Thanh Nho Do, T. Thang Vo‐Doan   +5 more
wiley   +1 more source

Lipid Droplet‐Organized MDM2‐Mediated P53 Degradation: A Metabolic Switch Governing Diet‐Driven Tumor Progression

Advanced Science, EarlyView.
Tumor‐associated TP53 inactivation correlates with lipid droplet (LD) accumulation. High‐fat diets drive Cyb5r3‐Myh9‐mediated p53 enrichment on LD surfaces, accelerating its degradation while upregulating LD‐promoting factor CD36 expression to establish a feed‐forward loop. LD suppression or dietary intervention restores p53 and inhibits tumorigenesis,
Haiyang Liu, Lin Jing, Yixin Li, Jinxing Zhou, Xiaohui Cui, Sen Li, Shijie Yang, Fangming Kan, Junfeng Du, Wentao Zhong, Sheng Yu, Ning Wang, Xing Jia, Junhui Li, Pan Nie, Zhenzhong Chen, Ying Han, Lingxi Jiang, Xiyun Yan, Hongxia Duan, Baiyong Shen   +20 more
wiley   +1 more source

Effect of general anaesthesia with remimazolam versus propofol on postoperative quality of recovery in patients undergoing ambulatory arthroscopic meniscus repair: a randomised clinical trial

BJA Open, 2023
Background: The type of anaesthesia and choice of anaesthetic drugs may affect the quality of recovery after surgery. Remimazolam is a new benzodiazepine with rapid onset and offset, specifically antagonised by flumazenil.
Lili Tang, Yue Sun, Xixi Hao, Xuemei Sun, Cuiyu Xie, Tingting Wang, Chengyang Hu, Yao Lu, Xuesheng Liu   +8 more
doaj  

Multi‐Omics and ‐Organ Insights into Energy Metabolic Adaptations in Early Sepsis Onset

Advanced Science, EarlyView.
This study shows that patients at risk of sepsis have a distinct metabolite and lipid signature, including serine and aminoadipic acid, in their serum before clinical diagnosis. A mouse model of sepsis with a compatible serum signature reveals underlying metabolic changes, including mitochondrial adaptation, altered serine‐dependent purine metabolism ...
Lin‐Lin Xu, Zhengyuan Zhou, Sascha Schäuble, Wolfgang Vivas, Karen Dlubatz, Michael Bauer, Sebastian Weis, Mervyn Singer, Roman Lukaszewski, Gianni Panagiotou   +9 more
wiley   +1 more source

Muscle mass and intramuscular fat of the quadriceps are related to muscle strength in non-ambulatory chronic stroke survivors: A cross-sectional study

PLoS ONE, 2018
Objective Improving muscle mass and intramuscular fat in the mid-thigh increases the muscle strength of the paretic and non-paretic limbs in ambulatory chronic stroke survivors.
N. Akazawa, K. Harada, N. Okawa, K. Tamura, H. Moriyama   +4 more
semanticscholar   +1 more source

Patient anxiety and conscious surgery [PDF]

, 2009
The amount of surgery undertaken on the conscious patient is increasing. However, many patients are anxious and resistant to such surgery. Patients (n=214) were surveyed to determine their related apprehensions.
Mitchell, MJ
core   +1 more source

Igfbp2 Downregulation in PVT‐CeA Glutamatergic Circuits Drives Neonatal Anesthesia‐Induced Fear Memory Deficits

Advanced Science, EarlyView.
Repeated neonatal sevoflurane exposure impairs adolescent fear memory through Igfbp2 downregulation in paraventricular thalamus‐central amygdala glutamatergic projections. Restoring Igfbp2 or activating this circuit rescues memory deficits, neuronal excitability, and spine density, identifying a precise molecular target for preventing anesthesia ...
Weiming Zhao, Ke Peng, Baojian Zhao, Xiaowen Meng, Gang Wang, Hanbing Xu, Li Deng, Xisheng Shan, Yichan Wang, Qiya Xu, Yanan Gao, Ruixia Weng, Hong Liu, Jin Tao, Huayue Liu, Shaoyong Song, Fuhai Ji   +16 more
wiley   +1 more source

The Long Noncoding RNA ΒFaar Promotes White Adipose Tissue Browning and Prevents Diet‐Induced Obesity

Advanced Science, EarlyView.
βFaar selectively targets and inhibits the GTPase activity of the RAB18 protein, thereby reducing LD volume. Conversely, βFaar promotes nuclear translocation of the transcription factor IRF4 in inguinal white adipose tissue (iWAT), facilitating the browning of white adipose tissue and attenuating body fat accumulation.
Yue Yang, Bin Huang, Baixue Sha, Danni Gao, Yimeng Qin, Ziyi Li, Xi Chen, Yinuo Jin, Yi Pan, Yanfeng Zhang, Yumeng Shen, Yu Liu, Liang Jin, Fangfang Zhang   +13 more
wiley   +1 more source

EPILEPTIC AMBULATORY AUTOMATISM [PDF]

The Journal of Nervous and Mental Disease, 1900
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openaire   +2 more sources