Results 191 to 200 of about 4,300,939 (300)

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock   +9 more
wiley   +1 more source

A New Case of Lethal Congenital Contracture Syndrome Type 3 With Hyperinsulinism and Optic Atrophy

open access: yesClinical Genetics, EarlyView.
PIP5K1C‐related lethal congenital contracture syndrome with hyperinsulinism and optic atrophy. ABSTRACT Lethal congenital contracture syndrome 3 (LCCS3, MIM #611369) is a rare autosomal recessive neuromuscular disorder caused by biallelic loss‐of‐function (LOF) variants in PIP5K1C, reported in only two families to date.
Tameemi Abdalla Moady   +3 more
wiley   +1 more source

Effect of interdisciplinary obesity care on metabolic markers and body weight in people with type 2 diabetes in a rural setting: A randomised controlled trial

open access: yesClinical Obesity, Volume 15, Issue 2, April 2025.
Summary Management of type 2 diabetes includes medications that can unintentionally increase obesity and insulin resistance. This unblinded, single‐centre, randomised controlled trial focused on rural Australian adults with type 2 diabetes (aged 18–75 and body mass index [BMI] >30 kg/m2), measuring the effectiveness of a tailored interdisciplinary ...
Giuliana O. Murfet   +3 more
wiley   +1 more source

Immersive virtual reality arm exercise, physical activity, and cardiometabolic health in cerebral palsy: A phase 1 trial

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
In this pilot randomized trial, 32 young people with cerebral palsy used seated, telehealth‐delivered virtual reality exergaming for 12 weeks. Participants averaged 144 minutes per week of exercise and self‐reported physical activity increased by up to 166%, with favorable early changes in insulin (−45%) and triglycerides (−20%), while a waitlist ...
Byron Lai   +10 more
wiley   +1 more source

Physical therapy interventions for children and adolescents with myelomeningocele: A systematic review

open access: yesDevelopmental Medicine &Child Neurology, EarlyView.
Abstract Aim To systematically review the current evidence on physical therapy interventions for children and adolescents with myelomeningocele, the most complex and common presentation of spina bifida, to explore intervention components and the outcomes according to International Classification of Functioning, Disability and Health (ICF) domains, and ...
Lorena Costa Ferreira   +3 more
wiley   +1 more source

Home - About - Disclaimer - Privacy