Results 321 to 330 of about 274,568 (352)

Impacts of Pharmacokinetic Gene Polymorphisms on Steady‐State Plasma Concentrations of Simvastatin in Thai Population

open access: yesClinical and Translational Science, Volume 18, Issue 5, May 2025.
ABSTRACT Simvastatin, an HMG‐CoA reductase inhibitor, is widely used for hypercholesterolemia but may cause myotoxicity linked to its plasma concentration. Pharmacokinetic gene polymorphisms influence inter‐individual variability in simvastatin exposure.
Sayanit Tipnoppanon   +10 more
wiley   +1 more source

Protein Biomarkers in Venous Leg Ulcer Fluid: A Systematic Review

open access: yesInternational Wound Journal, Volume 22, Issue 5, May 2025.
ABSTRACT Venous leg ulcers (VLUs) are common and cause significant morbidity and poor quality of life. There is a poor understanding of the biology underlying non‐healing VLUs. VLU exudates may reflect the underlying wound microenvironment. This systematic review aims to identify potentially diagnostic and/or prognostic protein biomarkers within VLU ...
Renitha Reddi   +3 more
wiley   +1 more source

Aerobic, Resistance, and Isometric Exercise to Reduce Blood Pressure Variability: A Network Meta‐Analysis of 15 Clinical Trials

open access: yesThe Journal of Clinical Hypertension, Volume 27, Issue 5, May 2025.
ABSTRACT Elevated blood pressure variability (BPV) is an emerging independent risk factor for increased cardiovascular diseases (CVD). Many studies are exploring the impacts of regular physical exercise on reducing BPV. This study aimed to investigate whether exercise can be an intervention to control for the short‐term and long‐term BPV.
Ziyu Hao   +4 more
wiley   +1 more source

D‐ and L‐Amino Acid Blood Concentrations Are Affected in Children With Duchenne Muscular Dystrophy

open access: yesJournal of Cellular and Molecular Medicine, Volume 29, Issue 9, May 2025.
ABSTRACT Duchenne muscular dystrophy (DMD) is an X‐linked disease caused by the absence of functional dystrophin in the muscle cells. Recent untargeted metabolomics studies identified amino acid metabolism alterations as biochemical pathways potentially involved in DMD pathogenesis.
Martina Garofalo   +9 more
wiley   +1 more source

Association of bodyweight loss with changes in lipids, blood pressure, and fasting serum glucose following tirzepatide treatment in Japanese participants with type 2 diabetes: A post hoc analysis of the SURPASS J‐mono trial

open access: yesJournal of Diabetes Investigation, Volume 16, Issue 5, Page 807-816, May 2025.
In SURPASS J‐mono, tirzepatide‐mediated non‐glycemic and glycemic parameter improvements appeared differentially associated with weight loss, suggesting both weight loss‐associated and ‐unassociated effects of tirzepatide. ABSTRACT Aims/Introduction In the SURPASS J‐mono trial, tirzepatide demonstrated significant improvements in bodyweight and several
Hanaka Mimura   +5 more
wiley   +1 more source

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