Results 151 to 160 of about 67,809 (311)

Treatment Continuation and Long‐Term Outcomes of Perampanel in Primary Orthostatic Tremor; A Cohort Study

open access: yesMovement Disorders Clinical Practice, EarlyView.
Background Primary orthostatic tremor (POT) is a rare hyperkinetic movement disorder with limited and largely ineffective treatment options. Perampanel has been suggested as a therapy, but has so far only been investigated in small studies with short duration.
Wietske A. Babeliowsky   +4 more
wiley   +1 more source

Metabolic and Volumetric Alterations in the Basal Ganglia and the Cerebellum in Dopa‐Responsive Dystonia in Symptomatic and Asymptomatic GCH1 Mutation Carriers

open access: yesMovement Disorders, EarlyView.
ABSTRACT Background Dopa‐responsive dystonia is caused by pathogenic variants in the GCH1 gene. Although its clinical features and reduced penetrance are known, in vivo metabolic and structural alterations in symptomatic (sMC) and asymptomatic mutation carriers (aMC) remain poorly understood.
Jannik Prasuhn   +12 more
wiley   +1 more source

Information Design for Early‐Stage Dose‐Finding Trials

open access: yesNaval Research Logistics (NRL), EarlyView.
ABSTRACT To enhance enrollment rates in early‐stage dose‐finding clinical trials, we propose an information design approach, where the clinical investigator (CI) commits to an information releasing mechanism (IRM) based on the treatment's uncertain efficacy and toxicity to encourage patients to participate in the trial.
Amin Khademi, Ningyuan Chen
wiley   +1 more source

Social Determinants of Spinal Pathology in Adolescents From Urban Centers in the Post‐Medieval Netherlands (1650–1850 CE)

open access: yesInternational Journal of Osteoarchaeology, EarlyView.
ABSTRACT The study of trauma in individuals undergoing growth and development remains an understudied area of research but can provide unique insights into the lived experiences and social identities of young people in the past. This study examines vertebral compression fractures and Schmorl's nodes in children and adolescents (1–20 years at death ...
Meghan D. Langlois   +3 more
wiley   +1 more source

The Reliability of Intraoperative Frozen Section for Glottic Lesions Suspected of Early Malignancy

open access: yesOtolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective Glottic lesions suspected of malignancy may be treated by laser cordectomy. Although obviating the preoperative biopsy can expedite treatment and preserve the surgical planes, it poses a risk of mistreatment. This study sought to determine if intraoperative frozen section (FS) prior to cordectomy can reliably guide lesion management.
Gal Levi   +5 more
wiley   +1 more source

Hydroxyl‐Terminated Polybutadiene‐Based Molding Powders as an Alternative Route for Manufacturing Pressed Polymer‐Bonded Explosives

open access: yesPropellants, Explosives, Pyrotechnics, EarlyView.
This study presents an alternative method to manufacture polymer‐bonded explosives by partially curing an HTPB‐based molding powder prior to compaction. The study shows that the length of partial cure time before compaction directly influenced the geometric fidelity, homogeneity, compressive strength, density, and internal microstructure.
Ismar L. Chew   +4 more
wiley   +1 more source

Home - About - Disclaimer - Privacy