Results 121 to 130 of about 529 (192)

Lithospermic Acid Improves Doxorubicin‐Induced Cardiomyopathy Through Sirtuin‐3‐Mediated Deacetylation of p53

Phytotherapy Research, EarlyView.
Lithospermic acid (LA) inactivates the p53 signaling pathway via directly targeting SIRT3, thereby alleviating oxidative stress and abnormal apoptosis in the progression of doxorubicin (Dox)‐induced cardiomyocytes. ABSTRACT Doxorubicin (Dox)‐induced cardiomyopathy (DIC) is characterized by significant myocardial damage that can progress to dilated ...
Yining Zhao, Tao Xu, Chao Ye, Ke Zhang, Xinyu Heng, Shaohong Huang, Yan Chen, Yitong Guo, Shengyi Shao, Zhi Wen, Chenwen Shao, Xiang Lu, Ning Sun, Hai Yang   +13 more
wiley   +1 more source

Bridging Psychological Stress and Skin Cellular Aging: Flavonoids as a Dual‐Action Therapeutic Strategy

Phytotherapy Research, EarlyView.
ABSTRACT Psychological stress (or simply “stress”) is a major contributor to chronic disease worldwide, affecting 35% of the global population, including younger generations. Furthermore, it plays a significant role in human premature aging; hence, its detrimental effects on people's health compel us to comprehend and control the ways in which ...
Marco Duarte, Sílvia Santos Pedrosa, P. Raaj Khusial, Ana Raquel Madureira   +3 more
wiley   +1 more source

Comparative transcriptomic analyses of diploid and tetraploid citrus reveal how ploidy level influences salt stress tolerance. [PDF]

Front Plant Sci
Bonnin M, Soriano A, Favreau B, Lourkisti R, Miranda M, Ollitrault P, Oustric J, Berti L, Santini J, Morillon R.   +9 more
europepmc   +1 more source

Advances in Elemene Nanodelivery Systems: From Material Design to Disease Treatment

Rare Metals, EarlyView.
ABSTRACT Elemene (ELE) is a bioactive sesquiterpenoid extracted from traditional Chinese herbs, demonstrating broad‐spectrum antitumor, anti‐inflammatory, and analgesic properties with significant therapeutic potential. However, its clinical utility is constrained by inherent physicochemical limitations, including volatility and hydrophobicity, which ...
Xiao Wang, Jiatong Lin, Yi Peng, Zehua Wu, Yingying Liu, Wei Duan, Qiaolin Wei, Jia‐Wei Shen, Jiang‐Xing Chen, Yong Guo   +9 more
wiley   +1 more source

Avoiding the ‘One‐Size‐Fits‐All’ Trap in Policy‐Based Monitoring

River Research and Applications, EarlyView.
ABSTRACT Policy‐based monitoring programmes often fail to yield the information required to assess and improve policies and plans. A dominant cause of this problem is the ‘one‐size‐fits‐all’ (OSFA) trap—a failure to recognise that several, complementary types of monitoring are required to support effective policy.
Rick J. Stoffels, Ross M. Thompson
wiley   +1 more source

The <i>Silene latifolia</i> genome and its giant Y chromosome. [PDF]

Science
Moraga C, Branco C, Rougemont Q, Jedlička P, Mendoza-Galindo E, Veltsos P, Hanique M, Rodríguez de la Vega RC, Tannier E, Liu X, Lemaitre C, Fields PD, Cruaud C, Labadie K, Belser C, Briolay J, Santoni S, Cegan R, Linheiro R, Adam G, El Filali A, Mossion V, Boualem A, Tavares R, Chebbi A, Cordaux R, Fruchard C, Prentout D, Velt A, Spataro B, Delmotte S, Weingartner L, Toegelová H, Tulpová Z, Cápal P, Šimková H, Štorchová H, Krüger M, Abeyawardana OAJ, Taylor DR, Olson MS, Sloan DB, Karrenberg S, Delph LF, Charlesworth D, Muyle A, Giraud T, Bendahmane A, Di Genova A, Madoui MA, Hobza R, Marais GAB.   +51 more
europepmc   +1 more source

Resource reallocation across successive systemic innovations: How Rolls‐Royce shaped the evolution of the turbojet, turboprop, and turbofan

Strategic Management Journal, EarlyView.
Abstract Research Summary Despite the importance of resource reallocation in shaping a variety of strategic outcomes, strategy scholars have paid only limited attention to the processes by which firms reallocate their resources across successive systemic innovations.
Gino Cattani, Mariano Mastrogiorgio, Giuseppe Carignani   +2 more
wiley   +1 more source

Genomic evidence of genuine wild versus admixed olive populations evolving in the same natural environments in western Mediterranean Basin. [PDF]

PLoS One
Zunino L, Cubry P, Sarah G, Mournet P, El Bakkali A, Aqbouch L, Sidibé-Bocs S, Costes E, Khadari B.   +8 more
europepmc   +1 more source

Measuring Strategic, Tactical, Complex and Simple Changes to Farm Systems

Systems Research and Behavioral Science, EarlyView.
ABSTRACT Agriculture is under increasing pressure to redesign farm systems. Governments are increasingly seeking to halt or reverse the damaging effects of agriculture on the environment. Adapting to climate change requires reconfiguring farm systems to withstand more variable, and historically more extreme, seasonal conditions and the constant demand ...
Geoff Kaine, Vic Wright
wiley   +1 more source