Distribution of the amelogenin protein in developing, injured and carious human teeth [PDF]
Frontiers in Physiology, 2014 Amelogenin is the major enamel matrix protein with key roles in amelogenesis. Although for many decades amelogenin was considered to be exclusively expressed by ameloblasts, more recent studies have shown that amelogenin is also expressed in other dental
Thimios eMitsiadis +5 more
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Preparative SDS PAGE as an Alternative to His-Tag Purification of Recombinant Amelogenin [PDF]
Frontiers in Physiology, 2017 Recombinant protein technology provides an invaluable source of proteins for use in structure-function studies, as immunogens, and in the development of therapeutics.
Claire M. Gabe +2 more
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Amelogenin Peptide Promotes Human Dental Pulp Cell Proliferation and Odontogenic Differentiation via ERK1/2 Pathway [PDF]
International Dental JournalObjectives: Enamel matrix derivative (EMD) is widely recognized for its ability to induce osteogenic and odontogenic differentiation. However, the complex composition of EMD frequently results to inconsistent experimental and clinical outcomes ...
Zhaoxia Yu +10 more
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Amelogenin Peptide Extract Increases Differentiation and Angiogenic and Local Factor Production and Inhibits Apoptosis in Human Osteoblasts [PDF]
, 2013 Enamel matrix derivative (EMD), a decellularized porcine extracellular matrix (ECM), is used clinically in periodontal tissue regeneration. Amelogenin, EMD’s principal component, spontaneously assembles into nanospheres in vivo, forming an ECM complex ...
Almaguer-Flores, Argelia +6 more
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Effect of the recombinant amelogenin peptide TRAP on remineralization of early enamel caries: an in-situ study [PDF]
BMC Oral HealthBackground The tyrosine-rich amelogenin peptide (TRAP) is the main enzymatic hydrolysis product of amelogenin during enamel development. The TRAP peptide has been shown to promote the remineralization of early enamel caries in vitro.
Qinghua Bai +5 more
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Prolonged skin allograft survival by rM180 amelogenin in a murine skin transplantation model [PDF]
Frontiers in ImmunologyIntroductionAmelogenin, used as a periodontal tissue regeneration material, promotes healing after periodontal surgery. A previous study has demonstrated that amelogenin is taken up by macrophages into the nucleus and inhibits major histocompatibility ...
Miyu Shida +12 more
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Forensic Science International: Synergy, 2023 The Amelogenin sex test included in forensic DNA typing kits has the potential to identify congenital conditions such as differences/disorders of sex development (DSD).
Alessandro Gabriele +5 more
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Effects of Amelogenin on Proliferation, Differentiation, and Mineralization of Rat Bone Marrow Mesenchymal Stem Cells In Vitro [PDF]
The Scientific World Journal, 2012 The aim of this study was to clarify the function of amelogenin, the major protein of enamel matrix derivative, on the proliferation, differentiation, and mineralization of cultured rat bone marrow stem cells (BMSCs), toward the establishment of future ...
Masanobu Izumikawa +4 more
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Effect of Recombinant Human Amelogenin on the Osteogenic Differentiation Potential of SHED [PDF]
CellsThis study aimed to explore how amelogenin can improve stem cells from human exfoliated deciduous teeth (SHED)–based bone regeneration and promote tissue healing as a treatment for critical-sized bone defects.
Akira Hirabae +7 more
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Journal of Oral Biology and Craniofacial Research, 2022 Vitality of the dentin-pulp complex depends on cell activity and signalling processes. Amelogenin protein regulates cell signalling pathways during tooth development by activating the Wnt/β-catenin intercellular signalling pathway.
Maha M.F. Mounir +2 more
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