Results 21 to 30 of about 5,635 (209)
Amelogenin supramolecular assembly in nanospheres defined by a complex helix-coil-PPII helix 3D-structure. [PDF]
PLoS ONE, 2011 Tooth enamel, the hardest material in the human body, is formed within a self-assembled matrix consisting mostly of amelogenin proteins. Here we have determined the complete mouse amelogenin structure under physiological conditions and defined ...
Xu Zhang +3 more
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Distribution of the amelogenin protein in developing, injured and carious human teeth
Frontiers in Physiology, 2014 Amelogenin is the major enamel matrix protein with key roles in amelogenesis. Although for many decades amelogenin was considered to be exclusively expressed by ameloblasts, more recent studies have shown that amelogenin is also expressed in other dental
Thimios eMitsiadis +5 more
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The Leucine-Rich Amelogenin Peptide Alters the Amelogenin Null Enamel Phenotype [PDF]
Cells Tissues Organs, 2008 <i>Introduction:</i> The amelogenin proteins secreted by ameloblasts during dental enamel development are required for normal enamel structure. <i>Amelx</i> null (KO) mice have hypoplastic, disorganized enamel similar to that of human patients with mutations in the <i>AMELX</i> gene, and provide a model system for ...
Yong Li +9 more
openaire +3 more sources
Use of human amelogenin in molecular encapsulation for the design of pH responsive microparticles
BMC Biotechnology, 2012 Background Proteins can be used in drug delivery systems to improve pharmacological properties of an active substance. Differences in pH between tissues can be utilized in order to achieve a targeted drug release at a specific location or tissue, such as
Bonde Johan, Bülow Leif
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Molar incisor hypomineralisation: current knowledge and practice
International Dental Journal, EarlyView., 2020 Background Molar incisor hypomineralisation (MIH) is a common developmental dental condition that presents in childhood. Areas of poorly formed enamel affect one or more first permanent molars and can cause opacities on the anterior teeth. MIH presents a variety of challenges for the dental team as well as functional and social impacts for affected ...
Helen D. Rodd +4 more
wiley +1 more source
Weaker dental enamel explains dental decay. [PDF]
PLoS ONE, 2015 Dental caries continues to be the most prevalent bacteria-mediated non-contagious disease of humankind. Dental professionals assert the disease can be explained by poor oral hygiene and a diet rich in sugars but this does not account for caries free ...
Alexandre R Vieira +4 more
doaj +1 more source
Frontiers in Physiology, 2014 The hardest tooth enamel tissue develops from a soft layer of protein-rich matrix, predominated by amelogenin that is secreted by epithelial ameloblasts in the secretory stage of tooth enamel development.
Li eZhu +5 more
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Frontiers in Physiology, 2022 Tooth enamel develops within a pH sensitive amelogenin-rich protein matrix. The purpose of the present study is to shed light on the intimate relationship between enamel matrix pH, enamel protein self-assembly, and enamel crystal growth during early ...
Youbin Zhang +10 more
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Amelogenin: lessons from evolution [PDF]
Archives of Oral Biology, 2005 Amelogenin plays a crucial role in enamel structure and mineralization, but the function of its various domains is far to be understood. Evolutionary analysis seems to be a promising way to approach structure/function relationships. In this paper, we review the knowledge of amelogenin with a particular focus on what we have learnt from evolution, and ...
Jean-Yves Sire +3 more
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Dose-Dependent Rescue of KO Amelogenin Enamel by Transgenes in Vivo
Frontiers in Physiology, 2017 Mice lacking amelogenin (KO) have hypoplastic enamel. Overexpression of the most abundant amelogenin splice variant M180 and LRAP transgenes can substantially improve KO enamel, but only ~40% of the incisor thickness is recovered and the prisms are not ...
Felicitas B. Bidlack +4 more
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