Results 21 to 30 of about 5,706 (208)

The Leucine-Rich Amelogenin Peptide Alters the Amelogenin Null Enamel Phenotype [PDF]

Cells Tissues Organs, 2008
<i>Introduction:</i> The amelogenin proteins secreted by ameloblasts during dental enamel development are required for normal enamel structure. <i>Amelx</i> null (KO) mice have hypoplastic, disorganized enamel similar to that of human patients with mutations in the <i>AMELX</i> gene, and provide a model system for ...
Yong Li, Carolyn W. Gibson, Melissa Aragon, Zhi An Yuan, Cynthia Suggs, Ashok B. Kulkarni, Hanson Fong, J. Timothy Wright, Darrin Simmons, Bill Daly   +9 more
openaire   +3 more sources

Molar incisor hypomineralisation: current knowledge and practice

International Dental Journal, EarlyView., 2020
Background Molar incisor hypomineralisation (MIH) is a common developmental dental condition that presents in childhood. Areas of poorly formed enamel affect one or more first permanent molars and can cause opacities on the anterior teeth. MIH presents a variety of challenges for the dental team as well as functional and social impacts for affected ...
Helen D. Rodd, Anna Graham, Niecoo Tajmehr, Laura Timms, Noren Hasmun   +4 more
wiley   +1 more source

Use of human amelogenin in molecular encapsulation for the design of pH responsive microparticles

BMC Biotechnology, 2012
Background Proteins can be used in drug delivery systems to improve pharmacological properties of an active substance. Differences in pH between tissues can be utilized in order to achieve a targeted drug release at a specific location or tissue, such as
Bonde Johan, Bülow Leif
doaj   +1 more source

Co-Occurrence of Ovarian Dysgerminoma-Inducing Gonadoblastoma and Two Distinct Mammary Carcinomas in a Dog: A Case Report and Review of the Literature. [PDF]

Vet Med Sci
Canine ovarian gonadoblastoma (GB) (with SALL4, OCT‐4, E‐cadherin, α‐inhibin, AE1/AE3, and WT‐1 immunoreactivity) and two mammary carcinomas have been described in a genetically normal female Spitz. The scarcity of GB in dogs, aberrant WT‐1 expression in the germ cell component, and lack of the AMELY gene are the most remarkable features of the present
Golchin D, Sasani F, Farzad-Mohajeri S, Tovhidifar M, Ashrafi Tamai I.   +4 more
europepmc   +2 more sources

Weaker dental enamel explains dental decay. [PDF]

PLoS ONE, 2015
Dental caries continues to be the most prevalent bacteria-mediated non-contagious disease of humankind. Dental professionals assert the disease can be explained by poor oral hygiene and a diet rich in sugars but this does not account for caries free ...
Alexandre R Vieira, Carolyn W Gibson, Kathleen Deeley, Hui Xue, Yong Li   +4 more
doaj   +1 more source

Preferential and selective degradation and removal of amelogenin adsorbed on hydroxyapatites by MMP20 and KLK4 in vitro

Frontiers in Physiology, 2014
The hardest tooth enamel tissue develops from a soft layer of protein-rich matrix, predominated by amelogenin that is secreted by epithelial ameloblasts in the secretory stage of tooth enamel development.
Li eZhu, HaiChuan eLiu, H. Ewa eWitkowska, YuLei eHuang, Kataro eTanimoto, Wu eLi   +5 more
doaj   +1 more source

Highly acidic pH facilitates enamel protein self-assembly, apatite crystal growth and enamel protein interactions in the early enamel matrix

Frontiers in Physiology, 2022
Tooth enamel develops within a pH sensitive amelogenin-rich protein matrix. The purpose of the present study is to shed light on the intimate relationship between enamel matrix pH, enamel protein self-assembly, and enamel crystal growth during early ...
Youbin Zhang, Tianquan Jin, Weiying Zhu, Mirali Pandya, Gokul Gopinathan, Michael Allen, David Reed, Timothy Keiderling, Xiubei Liao, Thomas G. H. Diekwisch, Thomas G. H. Diekwisch   +10 more
doaj   +1 more source

Regenerative potential of biphasic calcium phosphate and enamel matrix derivatives in the treatment of isolated interproximal intrabony defects: a randomized controlled trial [PDF]

Journal of Yeungnam Medical Science, 2022
Background The combined use of biomaterials for regeneration may have great biological relevance. This study aimed to compare the regenerative potential of biphasic calcium phosphate (BCP) alone and with growth factor enamel matrix derivatives (EMDs) for
Pritish Chandra Pal, Ashish Bali, Ramanarayana Boyapati, Sangita Show, Kanikanti Siva Tejaswi, Sourabh Khandelwal   +5 more
doaj   +1 more source

Amelogenin: lessons from evolution [PDF]

Archives of Oral Biology, 2005
Amelogenin plays a crucial role in enamel structure and mineralization, but the function of its various domains is far to be understood. Evolutionary analysis seems to be a promising way to approach structure/function relationships. In this paper, we review the knowledge of amelogenin with a particular focus on what we have learnt from evolution, and ...
Jean-Yves Sire, Delphine Fromentin, Marc Girondot, Sidney Delgado   +3 more
openaire   +3 more sources

Dose-Dependent Rescue of KO Amelogenin Enamel by Transgenes in Vivo

Frontiers in Physiology, 2017
Mice lacking amelogenin (KO) have hypoplastic enamel. Overexpression of the most abundant amelogenin splice variant M180 and LRAP transgenes can substantially improve KO enamel, but only ~40% of the incisor thickness is recovered and the prisms are not ...
Felicitas B. Bidlack, Felicitas B. Bidlack, Yan Xia, Megan K. Pugach, Megan K. Pugach   +4 more
doaj   +1 more source