Results 61 to 70 of about 5,706 (208)

The nucleation and growth of calcium phosphate by amelogenin [PDF]

Journal of Crystal Growth, 2007
The nucleation processes involved in calcium phosphate formation in tooth enamel are not well understood but are believed to involve proteins in the extracellular matrix. The ability of one enamel protein, amelogenin, to promote the nucleation and growth of calcium phosphate was studied in an in vitro system involving metastable supersaturated ...
Jenna L. Larson, Wendy J. Shaw, Barbara J. Tarasevich, James P. Simmer, Michael L. Paine, Malcolm L. Snead, Christopher J. Howard   +6 more
openaire   +3 more sources

A BiO‐Optimizing Site Targeted (BOOST) Approach to Periodontal Regeneration Through Local Doxycycline Prior to Surgery: A Randomized Clinical Trial

Journal of Periodontal Research, EarlyView.
Localized pre‐surgical modulation of inflammation using doxycycline (BOOST) improved early wound healing and enhanced clinical and radiographic outcomes of periodontal regeneration at 1 year, demonstrating significant benefits in terms of CAL gain, defect fill, and pocket closure compared to standard care.
Mario Aimetti, Giacomo Baima, Virginia Lorenzetti, Nargiz Aliyeva, Mario Bottone, Giulia Maria Mariani, Federica Romano   +6 more
wiley   +1 more source

Mimicking amelogenesis to remineralize enamel through co-assembly of PTL fibrils and CMC/ACP

Materials & Design, 2023
Enamel remineralization has important clinical value for the prevention and minimally invasive treatment of early enamel caries. Enamel matrix proteins (EMPs) are believed to play a key role in amelogenesis to regulate the growth and organization of ...
Yangyang Ye, Runqiu Lu, Hao Ren, Yang Yang, Tianqi Li, Xiangyu Zhang, Peng Yang, Xu Zhang   +7 more
doaj  

Tracking Endogenous Amelogenin and Ameloblastin In Vivo

PLoS ONE, 2014
Research on enamel matrix proteins (EMPs) is centered on understanding their role in enamel biomineralization and their bioactivity for tissue engineering. While therapeutic application of EMPs has been widely documented, their expression and biological function in non-enamel tissues is unclear.
Jacques, J., Hotton, D., De la Dure-Molla, M., Petit, S., Asselin, A., Kulkarni, AB., Gibson, CW., Brookes, SJ., Berdal, A., Isaac, J.   +9 more
openaire   +5 more sources

Inhibition of acyl‐CoA synthetase long‐chain isozymes decreases multiple myeloma cell proliferation and causes mitochondrial dysfunction

Molecular Oncology, Volume 19, Issue 6, Page 1687-1706, June 2025.
Triacsin C inhibition of the acyl‐CoA synthetase long chain (ACSL) family decreases multiple myeloma cell survival, proliferation, mitochondrial respiration, and membrane potential. Made with Biorender.com. Multiple myeloma (MM) is an incurable cancer of plasma cells with a 5‐year survival rate of 59%.
Connor S. Murphy, Heather Fairfield, Victoria E. DeMambro, Samaa Fadel, Carlos A. Gartner, Michelle Karam, Christian Potts, Princess Rodriguez, Ya‐Wei Qiang, Habib Hamidi, Xiangnan Guan, Calvin P. H. Vary, Michaela R. Reagan   +12 more
wiley   +1 more source

Amelogenin as a regenerative endodontic molecule for immature teeth with apical periodontitis. An experimental study

Journal of Oral Biology and Craniofacial Research, 2022
Vitality of the dentin-pulp complex depends on cell activity and signalling processes. Amelogenin protein regulates cell signalling pathways during tooth development by activating the Wnt/β-catenin intercellular signalling pathway.
Maha M.F. Mounir, Fatma M. Rashed, Sahar M. Bukhary   +2 more
doaj  

Phosphorylated and Non-phosphorylated Leucine Rich Amelogenin Peptide Differentially Affect Ameloblast Mineralization

Frontiers in Physiology, 2018
The Leucine Rich Amelogenin Peptide (LRAP) is a product of alternative splicing of the amelogenin gene. As full length amelogenin, LRAP has been shown, in precipitation experiments, to regulate hydroxyapatite (HAP) crystal formation depending on its ...
Elvire Le Norcy, Elvire Le Norcy, Julie Lesieur, Jeremy Sadoine, Gaël Y. Rochefort, Catherine Chaussain, Catherine Chaussain, Anne Poliard   +7 more
doaj   +1 more source

Design Principles Of Inorganic‐Protein Hybrid Materials for Biomedicine

Exploration, Volume 5, Issue 3, June 2025.
Inorganic protein hybrid materials (IPHMs) due to editable structure present unrivalled potential at the intersection of synthetic biology and materials science. The synthesis of IPHMs with a high degree of biosafety from bioactive units represents a shift in material design and synthesis.
Hao Liu, Xiaohui Liu, Hui Jiang, Xuemei Wang   +3 more
wiley   +1 more source

Identifying a Novel Causal FAM83H Variant for Autosomal Dominant Amelogenesis Imperfecta Using Exome‐Sequencing

Molecular Genetics &Genomic Medicine, Volume 13, Issue 6, June 2025.
A novel pathogenic, protein‐truncating variant p.(Ser352*) was detected in a disease‐causing FAM83H gene, which was in agreement with pathogenicity, co‐segregation analysis for ADHCAI. This variant is compared to the other protein‐truncating variants in the last coding exon and confirms that a shorter protein leads to more severe ADHCAI.
Rick Kamps, Herm Martens, Bart de Koning, Bert Smeets, Michel van Geel   +4 more
wiley   +1 more source

Amelogenin: a Protein to Smile About

PLoS Biology, 2009
​HowHow did we humans (and other vertebrates) get our sparkling smiles? The hard white coating on our teeth, the enamel, is made up of hydroxyapatite—the same mineral that forms our bones. In our teeth, hydroxyapatite is organized into parallel arrays of columnar apatite crystals called prisms. The growth and organization of enamel prisms is controlled
openaire   +5 more sources