Results 61 to 70 of about 13,126 (251)

Alternative Pathway for Methyl Supply through the Coupling of SHMT1 and PEMT to Maintain Astrocytic Homeostasis in Parkinson's Disease

Advanced Science, EarlyView.
In Parkinson's disease, SHMT1 downregulation disrupts its interaction with PEMT in astrocytes, reducing SAM levels. This leads to H3K4me1 hypomethylation and decreased Slc1a2/Glul expression, ultimately exacerbating neuroexcitotoxicity and dopaminergic neuron loss.
Yue‐Han Chen, Rong‐Xin Zhu, Nuo‐Xi Zhang, Ting‐Ting Sun, Xi‐Wei Zhang, Yu‐Jie Zhao, Ben‐Yu He, Hang Yao, Ren‐Hong Du, Lei Cao, Wen‐Bin Zhang, Wei‐Guo Liu, Yun Cai, Cong Wang, Gang Hu, Yao Wei, Yang Liu, Ming Lu   +17 more
wiley   +1 more source

A New Method for Sex Determination Based on Detection of SRY, STS and Amelogenin Gene Regions with Simultaneous Amplification of Their Homologous Sequences by a Multiplex PCR [PDF]

, 2011
We have developed a new method for sex determination based on simultaneous detection of the SRY (sex-determining region Y), STS (steroid sulfatase) and amelogenin (AMELX and AMELY) gene regions and their homologous sequences. The sex of 246 blood samples
Miyaishi, Satoru, Morikawa, Toshio, Yamamoto, Yuji   +2 more
core   +1 more source

In situ biomimetic materials for dentin repair

BMEMat, EarlyView.
This review primarily discusses the role and clinical application of key biomimetic materials for in situ dentin repair, providing a feasible foundation for future material and performance optimization in situ dentin regeneration. Abstract Dental defects, ranking among the most prevalent diseases globally, pose a serious threat to human health, with ...
Jingjing Deng, Siyi Ren, Xuliang Deng, Yan Wei   +3 more
wiley   +1 more source

Comparative calcium binding of leucine‐rich amelogenin peptide and full‐length amelogenin

European Journal of Oral Sciences, 2006
Leucine‐rich amelogenin peptide (LRAP) is an alternately spliced amelogenin. LRAP is known to bind to hydroxyapatite, and has been shown to signal mesenchymal cells to proliferate, but its function in enamel formation is unclear. The purpose of this study was to determine the calcium‐binding properties and structure of recombinant human LRAP (rLRAP ...
Le, Thuan Q, Gochin, Miriam, Featherstone, John DB, Li, Wu, DenBesten, Pamela K   +4 more
openaire   +4 more sources

Exon4 Amelogenin Transcripts in Enamel Biomineralization [PDF]

Journal of Dental Research, 2015
Amelogenins are proteins formed by alternative splicing of the amelogenin gene, and are essential for tooth enamel formation. However, the unique functions of various alternatively spliced amelogenins in enamel formation are not well understood. In this study, we determined the spatiotemporal location of amelogenins derived from transcripts containing
Stahl, J, Nakano, Y, Horst, J, Zhu, L, Le, M, Zhang, Y, Liu, H, Li, W, Besten, PK Den   +8 more
openaire   +4 more sources

Amelogenin Exon 5 Peptide Promotes Cell Proliferation and Osteogenic Differentiation in Human Dental Pulp Stem Cells

Applied Sciences, 2019
Amelogenin is a complex enamel matrix protein that consists of various molecular-size proteins and amino acids. A spliced form of amelogenin was identified that included exons 2, 3, 5, 6, and 7.
Hirohito Kato, Yoichiro Taguchi, Isao Yamawaki, Yaru Ruan, Qingchao Wu, Yuji Nakano, Norimasa Tsumori, Takaya Nakata, Masahiro Noguchi, Makoto Umeda   +9 more
doaj   +1 more source

Regeneration of injured articular cartilage using the recombinant human amelogenin protein

Bone & Joint Research, 2023
Aims: Cartilage injuries rarely heal spontaneously and often require surgical intervention, leading to the formation of biomechanically inferior fibrous tissue.
Omer Helwa-Shalom, Faris Saba, Elad Spitzer, Salem Hanhan, Koby Goren, Shany I. Markowitz, Dekel Shilo, Nissim Khaimov, Yechiel N. Gellman, Dan Deutsch, Anat Blumenfeld, Hani Nevo, Amir Haze   +12 more
doaj   +1 more source

Interaction of enamel matrix proteins with human periodontal ligament cells [PDF]

, 2016
Dorothy Hodgkin Postgraduate Award for research studies (jointly funded by the Engineering and Physical Sciences Research Council, UK, and by Institut Straumann) and the Research Discretionary Funds of the Periodontology Unit, UCL Eastman Dental ...
A Cate Ten, A Fincham, A Mumulidu, A Sculean, A-M Bashour, F Mallard, H Zhang, Harsh D. Amin, HD Amin, HD Amin, HD Amin, HD Amin, Irwin Olsen, J Cancino, J Shapiro, J Xu, JE Reseland, Jonathan Knowles, JW Chen, K Tompkins, L Kuru, M Heritier, M Narukawa, M Zeichner‐David, Michel Dard, MT Pauw Van der, N Donos, ND Gkranias, Nikolaos Donos, S Gestrelius, S Iacob, SR Schlueter, V Cattaneo, W Lee, W Singhatanadgit   +34 more
core   +2 more sources

Reduced Dietary Protein Induces Changes in the Dental Proteome

Journal of Experimental Zoology Part B: Molecular and Developmental Evolution, EarlyView.
Low dietary protein (10%) from normal (20%) does change protein expression in tooth proteome and alter developmental pathways. Among the significant protein expressions changes are actin‐based myosins, tooth, and bone development proteins. Perplexingly tooth size is not altered, suggesting more nuanced phenotypic response to low dietary protein in ...
Robert W. Burroughs, Christopher J. Percival, Natasha S. Vitek   +2 more
wiley   +1 more source

Amelogenin Downregulates Interferon Gamma-Induced Major Histocompatibility Complex Class II Expression Through Suppression of Euchromatin Formation in the Class II Transactivator Promoter IV Region in Macrophages

Frontiers in Immunology, 2020
Enamel matrix derivatives (EMDs)-based periodontal tissue regenerative therapy is known to promote healing with minimal inflammatory response after periodontal surgery, i. e., it promotes wound healing with reduced pain and swelling.
Karen Yotsumoto, Terukazu Sanui, Urara Tanaka, Hiroaki Yamato, Rehab Alshargabi, Takanori Shinjo, Yuki Nakao, Yukari Watanabe, Chikako Hayashi, Takaharu Taketomi, Takao Fukuda, Fusanori Nishimura   +11 more
doaj   +1 more source