Results 181 to 190 of about 3,471 (217)
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Antifungal effect of amentoflavone derived fromSelaginella tamariscina
Archives of Pharmacal Research, 2006Amentoflavone is a plant bif avonoid that was isolated from an ethyl acetate extract of the whole plant of Selaginella tamariscina (Beauv.) spring. 1D and 2D NMR spectroscopy including DEPT, HMQC, and HMBC were used to determine its structure. Amentoflavone exhibited potent antifungal activity against several pathogenic fungal strains but had a very ...
Hyun Jun Jung +2 more
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Chemopreventive mechanisms of amentoflavone: recent trends and advancements
Naunyn-Schmiedeberg's Archives of Pharmacology, 2023In parallel to the continuous rise of new cancer cases all over the world, the interest of scientific community in natural anticancer agents has steadily been increased. In the past decades, numerous phytochemicals have been shown to possess a strong anticancer potential in preclinical conditions.
Hardeep Singh, Tuli +8 more
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Amentoflavone: Structure, Resources, Bioactivity and Pharmacology
2023Amentoflavone is a naturally occurring biflavonoid first identified in Selaginella species in 1971. Even before amentoflavone was isolated from Selaginella, extracts of this plant were used extensively in traditional medicine for the treatment of various health problems.
Šamec, Dunja, Karalija, Erna
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Determinants of amentoflavone interaction at the GABAA receptor
European Journal of Pharmacology, 2005We investigated the recognition properties of different GABA(A) receptor subtypes and mutant receptors for the biflavonoid amentoflavone, a constituent of St. John's Wort. Radioligand binding studies showed that amentoflavone recognition paralleled that of the classical benzodiazepine diazepam in that it had little or no affinity for alpha4- or alpha6 ...
Reena S, Hansen +2 more
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Inhibition of tumor specific angiogenesis by amentoflavone
Biochemistry (Moscow), 2008The formation of new capillaries from existing blood vessels is critical for tumor growth and metastasis. In this study we report that amentoflavone, a biflavonoid from Biophytum sensitivum, could inhibit the process of angiogenesis. Amentoflavone at nontoxic concentrations (0.05-0.2 microg/ml) showed significant inhibition in the proliferation ...
C, Guruvayoorappan, G, Kuttan
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Amentoflavones from Callitris species
Phytochemistry, 1982Abstract The biflavonoid patterns of the leaves of five species of Callitris are characterized as amentoflavone based derivatives only. This contrasts markedly with the diversity of biflavones reported for northern genera of the Cupressaceae.
P.A. Gadek, C.J. Quinn
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Amentoflavone, a plant biflavone: A new potential anti-inflammatory agent
Archives of Pharmacal Research, 1998Biflavonoid is one of unique classes of naturally-occurring bioflavonoids. Certain biflavonoids including amentoflavone were previously reported to have inhibitory effect on the group II phospholipase A2 activity. Amentoflavone was also found to inhibit cyclooxygenase from guinea-pig epidermis without affecting lipoxygenase.
Kun Ho Son +2 more
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Brain-to-Plasma Distribution Ratio of the Biflavone Amentoflavone in the Mouse
Drug Metabolism Letters, 2008Amentoflavone crosses the blood-brain barrier in vitro but did not inhibit benzodiazepine binding in vivo suggesting poor brain permeability. This prompted us to examine its brain distribution in mice. After Hypericum perforatum and Gingko biloba extracts its brain concentrations were below the limit of quantification. Levels were consistently detected
Milena, Colovic +2 more
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The biflavonoid, amentoflavone degrades DNA in the presence of copper ions
Toxicology in Vitro, 2004Previous reports from this laboratory have shown that flavonoids including apigenin are capable of inducing oxidative DNA cleavage in the presence of copper ions. In the present report, we have examined the ability of amentoflavone, a biflavonoid which is a dimer of apigenin, to catalyze the degradation of DNA.
Qamar, Uddin +7 more
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